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ISSN: 0031-3939
Pediatria Polska - Polish Journal of Paediatrics
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4/2022
vol. 97
 
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abstract:
Case report

Romiplostim – an emergency treatment of intracranial haemorrhage in the course of severe primary immune thrombocytopaenia

Paweł Łaguna
1, 2
,
Aleksandra Sikorska
1
,
Joanna Kulik
1
,
Michał Matysiak
1, 2

  1. Department of Oncology, Paediatric Haematology, Clinical Transplantology and Paediatrics University Paediatric Hospital in Warsaw, Medical University of Warsaw, Warsaw, Poland
  2. Pediatric Teaching Clinical Hospital, Medical University of Warsaw University Clinical, Warsaw, Poland
Pediatr Pol 2022; 97 (4): 343-346
DOI: https://doi.org/10.5114/polp.2022.122870
Online publish date: 2022/12/30
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We present a case of a 16-year-old girl with newly diagnosed/persistent immune thrombocytopaenia (ITP) with a complication of intracranial haemorrhage. She did not respond adequately to first-line treatment, i.e. intravenous immunoglobulin infusions, glucocorticosteroids, and transfusion of platelets, and developed numerous bleeding complications. During the treatment she developed bleeding into the central nervous system, which is a rare and devastating complication of ITP. In such cases, the available data in the literature suggest a potential role of the thrombopoietin receptor agonist as a life-saving emergency treatment for severe, newly diagnosed immune thrombocytopaenia. The prognosis of our patient’s survival and neurological status was completely dependent on this treatment. After obtaining consent from the appropriate bioethics committee, romiplostim was administered to the patient, with a good response and without side effects.
keywords:

platelet count, ITP, intracranial haemorrhage, romiplostim