SOME RESULTS OF AN ANALYSIS OF POLYHYDRIC ALCOHOLS EFFECT ON DETOXICATION PROCESSES

Rheosorbilact action on antitoxic function of the kidneys has been analysed using the values of medium weight

molecules in patients with severe sepsis. The study design includes the criteria of inclusion, exclusion and cessation.

Patients with pyoceptic complications (mainly surgical abdominal sepsis) with signs of severe endotoxicosis, dopaminergic

activity (5-10 mcg/kg min), biochemical criteria of SS (lactate >4 mmole/l, С-reactive protein >2 standard departures from

the norm) and other signs of severe sepsis with generalized disorders in homeostasis (assessing the multiple organ damage

course by H.Celye-I.A. Yeriuhin scale- 20-27 points, MODS scale – 6-10 points) corresponded to the inclusion criterion. All

patients were provided with appropriate debridement and intensive traditional therapy.

For control studies we involved patients with systemic inflammatory response syndrome who had 2-3 signs of SIRS in stage

A. It was found that rheosorbilact activates the transportation of medium weight molecules out of the extracellular space

and increases their excretion by the renal nephrons in patients with severe sepsis. It was established that in severe sepsis

rheosorbilact provides a high level of excretion of medium weight molecules by suppressing processes of reabsorption in the

proximal nephron portions caused by peptidase dependent metabolism.