SWIMMING EXERCISE STIMULATES NEURO-GENESIS IN THE SUBVENTRICULAR ZONE VIA INCREASE IN SYNAPSIN I AND NERVE GROWTH FACTOR LEVELS

Chae C-H; S-L Jung; S-H An; B-Y Park; T-W Kim; S-W Wang; J-H Kim; H-C Lee; H-T Kim

doi:10.5604/20831862.1132130

eISSN: 2083-1862
ISSN: 0860-021X

Biology of Sport

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4/2014
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abstract:

Original paper

SWIMMING EXERCISE STIMULATES NEURO-GENESIS IN THE SUBVENTRICULAR ZONE VIA INCREASE IN SYNAPSIN I AND NERVE GROWTH FACTOR LEVELS

Chae C-H

,

S-L Jung

,

S-H An

,

B-Y Park

,

T-W Kim

,

S-W Wang

,

J-H Kim

,

H-C Lee

,

H-T Kim

Biol. Sport 2014;31:309-314

DOI: https://doi.org/10.5604/20831862.1132130

Online publish date: 2015/01/08

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In this study, we investigated the effects of 8-weeks of swimming exercise on neurogenesis in the subventricular zone (SVZ) and on the levels of nerve growth factor (NGF) and synapsin I protein in the olfactory bulb (OB) of adult rats at a series of relevant time points (2 days, 1 week, 2 weeks, 4 weeks, 3 months, and

6 months). Ninety-six male Sprague Dawley rats were divided into 2 groups: (1) a control group (COG; n = 48, n = 8 for each time point) and (2) a swimming exercise group (SEG; total n = 48; n = 8 for each time point). SEG performed swimming exercise for 5 days per week over a period of 8 weeks. We found that the number of 5-bromo-2’-deoxyuridine-5’-monophosphate (BrdU)- and doublecortin (DCX)-positive cells was significantly higher in SEG than in COG at all time points (Day 2, Week 1, Week 2, Week 4, Month 3, and Month 6;

p < 0.001). Furthermore, NGF and synapsin I protein levels were significantly higher in SEG on Day 2, and Weeks 1, 2, and 4 than in COG (p < 0.05 for each time point). Our findings suggest that regular swimming exercise in adult rats increases neurogenesis, neuronal survival, and neuronal maintenance in the SVZ; furthermore, swimming exercise increases the levels of NGF and synapsin I in the OB.

keywords:

SWIMMING EXERCISE STIMULATES NEURO-GENESIS IN THE SUBVENTRICULAR ZONE VIA INCREASE IN SYNAPSIN I AND NERVE GROWTH FACTOR LEVELS

Chae C-H , S-L Jung , S-H An , B-Y Park , T-W Kim , S-W Wang , J-H Kim , H-C Lee , H-T Kim

physical training, progenitor cells, olfactory bulb, neurotrophic factors, brain, ratssurvival

Chae C-H

,

S-L Jung

,

S-H An

,

B-Y Park

,

T-W Kim

,

S-W Wang

,

J-H Kim

,

H-C Lee

,

H-T Kim