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eISSN: 2719-3209
ISSN: 0023-2157
Klinika Oczna / Acta Ophthalmologica Polonica
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SCImago Journal & Country Rank
3/2008
vol. 110
 
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abstract:
Original paper

Safety and efficacy of using bevacizumab in the treatment of exudative age-related macular degeneration

Maria Muzyka-Woźniak
1, 2
,
Jolanta Oficjalska-Młyńczak
1, 2
,
Bożena Gołębiowska
1

  1. Z Ośrodka Okulistyki Klinicznej NZOZ „Spektrum”
  2. Z Katedry i Kliniki Okulistyki Akademii Medycznej we Wrocławiu
Online publish date: 2008/09/15
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Purpose: To evaluate the efficacy and safety of intravitreal bevacizumab administered on “as required” basis in patients with

exudative age-related macular degeneration (AMD).

Material and methods: A prospective uncontrolled cohort study of patients with exudative AMD treated with intravitreal bevacizumab administered “as required” based on PRONTO reinjection criteria. Main outcome measures include standardized bestcorrected visual acuity (BCVA) and central macular thickness (CMT) measured with optical coherence tomography (Stratus

OCT).

Results: 153 eyes of 153 consecutive patients with AMD were treated with intravitreal bevacizumab injection, followed monthly

and reinjected “as required”. Mean follow-up time was 14.2 weeks (4-52 weeks). Distance BCVA improved from 0.79 log MAR

at baseline to 0.69 at 4 weeks, 0.7 at 8 weeks, 0.64 at 12 weeks, 0.71 at 16 weeks and 0.63 at 20 weeks (p<.05). Near BCVA

improved from 0.13 at baseline to 0.22 at 4 and 8 weeks, 0.25 at 12 weeks, 0.22 at 16 weeks and 0.28 at 20 weeks (p<.05).

Mean CMT decreased from 395 microm at baseline to 265 at 4 weeks, 260 at 8 weeks, 268 at 12 weeks, 255 at 16 weeks and

257 at 20 weeks (p<.05). Mean time between first and second injection was 91.9 days, and between second and third injection 99.7 days. No adverse events were observed.

Conclusions: Short-term results suggest that intravitreal bevaciuzmab administered “as required” is safe and effective in patients with exudative AMD. “As required” schedule may decrease the risk of adverse events and lower the cost of treatment.
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