Salivary and serum concentrations of selected pro- and antiinflammatory cytokines in relation to oral lesions among children undergoing maintenance therapy of acute lymphoblastic leukemia

Przemysław M. Krzaczek; Małgorzata Mitura-Lesiuk; Joanna Zawitkowska; Beata Petkowicz; Barbara Wilczyńska; Katarzyna Drabko

doi:10.5114/wo.2019.85878

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

Current issue Archive Manuscripts accepted About the journal Supplements Addendum Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

2/2019
vol. 23

Send email

Copy url:

abstract:

Original paper

Salivary and serum concentrations of selected pro- and antiinflammatory cytokines in relation to oral lesions among children undergoing maintenance therapy of acute lymphoblastic leukemia

Przemysław M. Krzaczek

¹

,

Małgorzata Mitura-Lesiuk

²

,

Joanna Zawitkowska

²

,

Beata Petkowicz

¹

,

Barbara Wilczyńska

³

,

Katarzyna Drabko

²

Department of Oral Medicine, Medical University of Lublin, Poland
Department of Hematology, Oncology and Pediatric Transplantology, II Chair of Pediatrics, Medical University of Lublin, Poland
Clinic of Pediatric Endocrinology and Diabetology with Endocrinological and Metabolic Laboratory, III Chair of Pediatrics, Medical University of Lublin, Poland

Contemp Oncol (Pozn) 2019; 23 (2): 81-86

DOI: https://doi.org/10.5114/wo.2019.85878

Online publish date: 2019/06/13

View full text Get citation

EndNote

Papers, Reference Manager, RefWorks, Zotero

AMA

Krzaczek P, Mitura-Lesiuk M, Zawitkowska J, Petkowicz B, Wilczyńska B, Drabko K. Salivary and serum concentrations of selected pro- and antiinflammatory cytokines in relation to oral lesions among children undergoing maintenance therapy of acute lymphoblastic leukemia. Contemporary Oncology/Współczesna Onkologia. 2019;23(2):81-86. doi:10.5114/wo.2019.85878.

APA

Krzaczek, P., Mitura-Lesiuk, M., Zawitkowska, J., Petkowicz, B., Wilczyńska, B.,  & Drabko, K. (2019). Salivary and serum concentrations of selected pro- and antiinflammatory cytokines in relation to oral lesions among children undergoing maintenance therapy of acute lymphoblastic leukemia. Contemporary Oncology/Współczesna Onkologia, 23(2), 81-86. https://doi.org/10.5114/wo.2019.85878

Chicago

Krzaczek, Przemysław M., Małgorzata Mitura-Lesiuk, Joanna Zawitkowska, Beata Petkowicz, Barbara Wilczyńska,  and Katarzyna Drabko. 2019. "Salivary and serum concentrations of selected pro- and antiinflammatory cytokines in relation to oral lesions among children undergoing maintenance therapy of acute lymphoblastic leukemia". Contemporary Oncology/Współczesna Onkologia 23 (2): 81-86. doi:10.5114/wo.2019.85878.

Harvard

Krzaczek, P., Mitura-Lesiuk, M., Zawitkowska, J., Petkowicz, B., Wilczyńska, B.,  and Drabko, K. (2019). Salivary and serum concentrations of selected pro- and antiinflammatory cytokines in relation to oral lesions among children undergoing maintenance therapy of acute lymphoblastic leukemia. Contemporary Oncology/Współczesna Onkologia, 23(2), pp.81-86. https://doi.org/10.5114/wo.2019.85878

MLA

Krzaczek, Przemysław M. et al. "Salivary and serum concentrations of selected pro- and antiinflammatory cytokines in relation to oral lesions among children undergoing maintenance therapy of acute lymphoblastic leukemia." Contemporary Oncology/Współczesna Onkologia, vol. 23, no. 2, 2019, pp. 81-86. doi:10.5114/wo.2019.85878.

Vancouver

Krzaczek P, Mitura-Lesiuk M, Zawitkowska J, Petkowicz B, Wilczyńska B, Drabko K. Salivary and serum concentrations of selected pro- and antiinflammatory cytokines in relation to oral lesions among children undergoing maintenance therapy of acute lymphoblastic leukemia. Contemporary Oncology/Współczesna Onkologia. 2019;23(2):81-86. doi:10.5114/wo.2019.85878.

PlumX metrics:

Acute lymphoblastic leukemia is the most common type of childhood cancer, accounting for about 23% of all cancers diagnosed in this age group. The last stage of radical treatment is remission maintenance, during which hospitalization is not necessary. The lesions occurring in the oral cavity caused by medications and chemotherapy may also be directly related to hematological and systemic disorders. The aim of this study was to examine the levels of selected pro- and anti-inflammatory cytokines in saliva and serum of both patients undergoing remission maintenance and those after the cessation of therapy who reported to the hematology clinic of the Pediatric University Hospital in Lublin. The results were later analyzed in relation to the frequency of oral lesions and subjective intensity of oral complaints. The study revealed significant differences in salivary and serum concentrations of TNF- and

IL-10 between test and control groups. Oral lesions were more frequent in patients receiving therapy compared to the control group. Subjective afflictions described by the Visual Analog Scale (VAS) mean values were highest in the control group.

keywords:

Salivary and serum concentrations of selected pro- and antiinflammatory cytokines in relation to oral lesions among children undergoing maintenance therapy of acute lymphoblastic leukemia

Przemysław M. Krzaczek 1 , Małgorzata Mitura-Lesiuk 2 , Joanna Zawitkowska 2 , Beata Petkowicz 1 , Barbara Wilczyńska 3 , Katarzyna Drabko 2

acute lymphoblastic leukemia, cytokines, oral lesions

Przemysław M. Krzaczek

¹

,

Małgorzata Mitura-Lesiuk

²

,

Joanna Zawitkowska

²

,

Beata Petkowicz

¹

,

Barbara Wilczyńska

³

,

Katarzyna Drabko

²