Saphenous graft atherosclerosis as assessed by optical coherence tomography data for stenotic and non-stenotic lesions from the OCTOPUS registry

Grzegorz Kubiak; Elżbieta Pociask; Wojciech Wańha; Magdalena Dobrolińska; Paweł Gąsior; Grzegorz Smolka; Andrzej Ochała; Zbigniew Gąsior; Wojciech Wojakowski; Tomasz Roleder

doi:10.5114/aic.2018.76407

eISSN: 1897-4295
ISSN: 1734-9338

Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej

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abstract:

Original paper

Saphenous graft atherosclerosis as assessed by optical coherence tomography data for stenotic and non-stenotic lesions from the OCTOPUS registry

Grzegorz M. Kubiak

,

Elżbieta Pociask

,

Wojciech Wańha

,

Magdalena Dobrolińska

,

Paweł Gąsior

,

Grzegorz Smolka

,

Andrzej Ochała

,

Zbigniew Gąsior

,

Wojciech Wojakowski

,

Tomasz Roleder

Adv Interv Cardiol 2018; 14, 2 (52): 157–166

DOI: https://doi.org/10.5114/aic.2018.76407

Online publish date: 2018/06/19

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AMA

Kubiak GM, Pociask E, Wańha W, et al. Saphenous graft atherosclerosis as assessed by optical coherence tomography data for stenotic and non-stenotic lesions from the OCTOPUS registry. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. 2018;14(2):157-166. doi:10.5114/aic.2018.76407.

APA

Kubiak, G. M., Pociask, E., Wańha, W., Dobrolińska, M., Gąsior, P.,  & Smolka, G. et al. (2018). Saphenous graft atherosclerosis as assessed by optical coherence tomography data for stenotic and non-stenotic lesions from the OCTOPUS registry. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej, 14(2), 157-166. https://doi.org/10.5114/aic.2018.76407

Chicago

Kubiak, Grzegorz M, Elżbieta Pociask, Wojciech Wańha, Magdalena Dobrolińska, Paweł Gąsior, Grzegorz Smolka,  and Andrzej Ochała et al. 2018. "Saphenous graft atherosclerosis as assessed by optical coherence tomography data for stenotic and non-stenotic lesions from the OCTOPUS registry". Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej 14 (2): 157-166. doi:10.5114/aic.2018.76407.

Harvard

Kubiak, G., Pociask, E., Wańha, W., Dobrolińska, M., Gąsior, P., Smolka, G., Ochała, A., Gąsior, Z., Wojakowski, W.,  and Roleder, T. (2018). Saphenous graft atherosclerosis as assessed by optical coherence tomography data for stenotic and non-stenotic lesions from the OCTOPUS registry. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej, 14(2), pp.157-166. https://doi.org/10.5114/aic.2018.76407

MLA

Kubiak, Grzegorz et al. "Saphenous graft atherosclerosis as assessed by optical coherence tomography data for stenotic and non-stenotic lesions from the OCTOPUS registry." Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej, vol. 14, no. 2, 2018, pp. 157-166. doi:10.5114/aic.2018.76407.

Vancouver

Kubiak G, Pociask E, Wańha W, Dobrolińska M, Gąsior P, Smolka G et al. Saphenous graft atherosclerosis as assessed by optical coherence tomography data for stenotic and non-stenotic lesions from the OCTOPUS registry. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. 2018;14(2):157-166. doi:10.5114/aic.2018.76407.

Introduction
Coronary artery bypass grafting (CABG), although widely used for a long time in diffuse coronary artery disease (CAD), has serious limitations associated with graft aging and its degeneration.

Aim
The relationship between saphenous vein graft (SVG) plaque morphology assessed by optical coherence tomography (OCT) and clinical findings has not been elucidated yet.

Material and methods
We compared the morphology of SVG in stenotic vs. non-stenotic lesions using OCT imaging in 29 patients hospitalized in our center within the OCTOPUS registry.

Results
Stenotic lesions were characterized by higher incidence of thin-cap fibroatheroma (TCFA) (33% vs. 0%, p = 0.0048), thrombus (28% vs. 0%, p = 0.0008), lipid-rich plaque (LRP) (75% vs. 35%, p = 0.0013) and plaque within the SVG valve (19% vs. 0%, p = 0.0114) as compared to non-stenotic lesions. Patients with intimal tearing or rupture (ITR) were older (75.8% vs. 68.9 years, p = 0.047) and had lower left ventricular ejection fraction (LVEF) (32.0% vs. 49.7%, p = 0.001) and glomerular filtration rate (GFR) (36.0 vs. 73.6 ml/min/1.73 m2, p = 0.010). Patients with calcified lesions vs. those without had lower high-density lipoprotein (HDL) cholesterol (33.2 vs. 44.1 mg/dl, p = 0.018), similarly to those with ruptured plaque vs. those without (28.3 vs. 41.7 mg/dl, p = 0.047).

Conclusions
Presence of ITR was associated with advanced age, decreased LVEF and renal insufficiency. Decreased concentration of HDL was associated with higher occurrence of calcified and ruptured plaque.

keywords:

Saphenous graft atherosclerosis as assessed by optical coherence tomography data for stenotic and non-stenotic lesions from the OCTOPUS registry

Grzegorz M. Kubiak , Elżbieta Pociask , Wojciech Wańha , Magdalena Dobrolińska , Paweł Gąsior , Grzegorz Smolka , Andrzej Ochała , Zbigniew Gąsior , Wojciech Wojakowski , Tomasz Roleder

coronary artery bypass grafting, saphenous vein graft, optical coherence tomography, thin-cap fibroatheroma, coronary artery disease

Grzegorz M. Kubiak

,

Elżbieta Pociask

,

Wojciech Wańha

,

Magdalena Dobrolińska

,

Paweł Gąsior

,

Grzegorz Smolka

,

Andrzej Ochała

,

Zbigniew Gąsior

,

Wojciech Wojakowski

,

Tomasz Roleder