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ISSN: 1233-9687
Polish Journal of Pathology
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4/2022
vol. 73
 
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abstract:
Original paper

Sarcoma – correlation between CD73 and PD-L1 and their relationship with prognosis

Abdullah Evren Yetişir
1
,
Semra Paydaş
2
,
Gülfiliz Gönlüşen
3
,
Kıvılcım Eren Erdoğan
3
,
Mahmut Büyükşimşek
1
,
Ali Oğul
1
,
Mert Tohumcuoğlu
1
,
Cem Mirili
4
,
Ayşegül Yetişir
5

  1. Department of Medical Oncology, Adana City Education and Research Hospital, Adana, Turkey
  2. Department of Oncology, Çukurova University Faculty of Medicine, Adana, Turkey
  3. Department of Pathology, Çukurova University Faculty of Medicine, Adana, Turkey
  4. Adana Private Hospital, Adana, Turkey
  5. Department of Physical Medicine and Rehabilitation, Çukurova University Faculty of Medicine, Adana, Turkey
Pol J Pathol 2022; 73 (4): 338-342
DOI: https://doi.org/10.5114/pjp.2022.125537
Online publish date: 2023/03/06
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This study aimed to evaluate CD73 and PD-L1 and determine their relationship with each other and with overall survival (OS) in sarcoma patients.

The paraffin blocks of 101 patients were analysed. 56.4% were female, and the mean age was 51.39 years. The mean OS was 20.73 months, and the Ki-67 proliferative index was 41.45. A positive correlation was found between CD73 tumour and CD73 tumour-infiltrating lymphocyte (TIL) findings. CD73 tumour and TIL findings were also positively correlated with PD-L1 percentages and PD-L1 intensity.

An inverse correlation was detected between OS and CD73 tumour and TIL groups of 5–25%, 25–50%, 50–75%, 75–90%, and > 90%, but no such correlation was found for the ≤ 5% group. There was an inverse correlation between OS and the PD-L1 percentages of <10% and > 50% and the PD-L1 intensity of weak-moderate and strong, but no correlation was found for the negative values. Lastly, an inverse correlation was found between OS and the Ki-67 proliferative index.

We found CD73 and PD-L1 positivity to be associated with decreased OS in sarcoma patients and determined a significant correlation between these parameters. This result is promising in terms of achieving better survival and disease control with anti-CD73 and anti-PD-L1 therapy in selected patients.
keywords:

sarcoma, CD73, PD-L1, overall survival
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