Scientific reports concerning the impact of interleukin 4, interleukin 10 and transforming growth factor  on cancer cells

Konrad Kwaśniak; Justyna Czarnik-Kwaśniak; Aleksandra Maziarz; David Aebisher; Kinga Zielińska; Bożenna Karczmarek-Borowska; Jacek Tabarkiewicz

doi:10.5114/ceji.2018.76273

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

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abstract:

Review paper

Scientific reports concerning the impact of interleukin 4, interleukin 10 and transforming growth factor  on cancer cells

Konrad Kwaśniak

¹

,

Justyna Czarnik-Kwaśniak

^{1, 2, 3}

,

Aleksandra Maziarz

^{1, 2}

,

David Aebisher

^{1, 2}

,

Kinga Zielińska

⁴

,

Bożenna Karczmarek-Borowska

^{4, 5}

,

Jacek Tabarkiewicz

^{1, 2}

Centre for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, University of Rzeszow, Poland
Department of Immunology, Faculty of Medicine, University of Rzeszow, Poland
Postgraduate School of Molecular Medicine, Medical University of Warsaw, Poland
Department of Clinical Oncology, Clinical Provincial Hospital No. 1 in Rzeszow, Poland
Department of Clinical Fundations of Physiotherapy, Medical Faculty, University of Rzeszow, Poland

(Centr Eur J Immunol 2019; 44 (2): 190-200)

DOI: https://doi.org/10.5114/ceji.2018.76273

Online publish date: 2019/07/30

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AMA

Kwaśniak K, Czarnik-Kwaśniak J, Maziarz A, et al. Scientific reports concerning the impact of interleukin 4, interleukin 10 and transforming growth factor  on cancer cells. Central European Journal of Immunology. 2019;44(2):190-200. doi:10.5114/ceji.2018.76273.

APA

Kwaśniak, K., Czarnik-Kwaśniak, J., Maziarz, A., Aebisher, D., Zielińska, K.,  & Karczmarek-Borowska, B. et al. (2019). Scientific reports concerning the impact of interleukin 4, interleukin 10 and transforming growth factor  on cancer cells. Central European Journal of Immunology, 44(2), 190-200. https://doi.org/10.5114/ceji.2018.76273

Chicago

Kwaśniak, Konrad, Justyna Czarnik-Kwaśniak, Aleksandra Maziarz, David Aebisher, Kinga Zielińska, Bożenna Karczmarek-Borowska,  and Jacek Tabarkiewicz. 2019. "Scientific reports concerning the impact of interleukin 4, interleukin 10 and transforming growth factor  on cancer cells". Central European Journal of Immunology 44 (2): 190-200. doi:10.5114/ceji.2018.76273.

Harvard

Kwaśniak, K., Czarnik-Kwaśniak, J., Maziarz, A., Aebisher, D., Zielińska, K., Karczmarek-Borowska, B.,  and Tabarkiewicz, J. (2019). Scientific reports concerning the impact of interleukin 4, interleukin 10 and transforming growth factor  on cancer cells. Central European Journal of Immunology, 44(2), pp.190-200. https://doi.org/10.5114/ceji.2018.76273

MLA

Kwaśniak, Konrad et al. "Scientific reports concerning the impact of interleukin 4, interleukin 10 and transforming growth factor  on cancer cells." Central European Journal of Immunology, vol. 44, no. 2, 2019, pp. 190-200. doi:10.5114/ceji.2018.76273.

Vancouver

Kwaśniak K, Czarnik-Kwaśniak J, Maziarz A, Aebisher D, Zielińska K, Karczmarek-Borowska B et al. Scientific reports concerning the impact of interleukin 4, interleukin 10 and transforming growth factor  on cancer cells. Central European Journal of Immunology. 2019;44(2):190-200. doi:10.5114/ceji.2018.76273.

PlumX metrics:

Cytokines are signalling proteins generated in most part by immune cells that have critical functions in cellular lifespan. Here we present recent data on three selected anti-inflammatory cytokines: interleukin (IL)-10, IL-4 and transforming growth factor  (TGF-). IL-10 inhibits the synthesis of major pro-inflammatory cytokines, chemokines, and mediates anti-inflammatory reactions. IL-4 is a multifunctional cytokine which plays a crucial role in the regulation of immune responses and is involved in processes associated with development and differentiation of lymphocytes and regulation of T cell survival. Transforming TGF-, which in normal cells or pre-cancerous cells, promotes proliferation arrest which represses tumour growth. In this review, we focus on the influence of IL-10, IL-4 and TGF- on various types of cancer as well as potential of these selected cytokines to serve as new biomarkers which can support effective therapies for cancer patients. This article is presented based on a review of the newest research results.

keywords:

Scientific reports concerning the impact of interleukin 4, interleukin 10 and transforming growth factor  on cancer cells

Konrad Kwaśniak 1 , Justyna Czarnik-Kwaśniak 1, 2, 3 , Aleksandra Maziarz 1, 2 , David Aebisher 1, 2 , Kinga Zielińska 4 , Bożenna Karczmarek-Borowska 4, 5 , Jacek Tabarkiewicz 1, 2

cancer, anti-inflammatory cytokines, IL-10, IL-4, TGF-

Konrad Kwaśniak

¹

,

Justyna Czarnik-Kwaśniak

^{1, 2, 3}

,

Aleksandra Maziarz

^{1, 2}

,

David Aebisher

^{1, 2}

,

Kinga Zielińska

⁴

,

Bożenna Karczmarek-Borowska

^{4, 5}

,

Jacek Tabarkiewicz

^{1, 2}