eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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3/2020
vol. 45
 
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abstract:
Review paper

Secondary immunodeficiencies with predominant antibody deficiency: multidisciplinary perspectives of Polish experts

Karina Jahnz-Różyk
1
,
Ewa Więsik-Szewczyk
1
,
Jacek Roliński
2
,
Maciej Siedlar
3
,
Wiesław Jędrzejczak
4
,
Wojciech Sydor
5
,
Agnieszka Tomaszewska
4

  1. Department of Internal Medicine, Pneumonology, Allergology and Clinical Immunology, Central Clinical Hospital of the Ministry of National Defense, Military Institute of Medicine, Warsaw, Poland
  2. Department of Clinical Immunology, Medical University of Lublin, Lublin, Poland
  3. Department of Clinical Immunology, Institute of Pediatrics, Jagiellonian University Medical College, Krakow, Poland
  4. Department of Hematology, Oncology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland
  5. Department of Rheumatology and Immunology, Jagiellonian University Medical College, Krakow, Poland
Cent Eur J Immunol 2019; 45 (3): 334-341
DOI: https://doi.org/10.5114/ceji.2020.101265
Online publish date: 2020/11/01
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At present, secondary immune deficiencies have become a clinical problem, recognized in different specialties. The aim of this paper was to increase awareness and support the need for screening at-risk populations. Secondary immune deficiencies result in variety of conditions, but not all of them require immunoglobulin replacement therapy, as specific antibody response might be preserved. Moreover, the management of secondary immune deficiencies vary between countries and different medical disciplines. This literature review presents the most common causes and clinical presentation of secondary immunodeficiencies with predominant impaired antibody production. We present diagnostic guidelines for patients at-risk, with an emphasis on the role of prophylactic vaccination as a treatment and diagnostic tool. This review considers the specificity and disparities of the Polish healthcare system and ultimately, suggests that management teams should include a clinical immunologist experienced in the treatment of humoral immunodeficiencies.
keywords:

secondary hypogammaglobulinemia, diagnostic workup, immunoglobulin substitution, antibody deficiency, rituximab, subcutaneous immunoglobulin
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