Segmental myocardial displacement and tissue velocity analysis of the right ventricle in hypoplastic left heart syndrome fetuses and controls using-Color Tissue Doppler Imaging (C-TDI)

Oliver Graupner; Christian Enzensberger; Larissa Wieg; Aline Wolter; Can Yerebakan; Markus Khalil; Roland Axt-Fliedner

eISSN: 2449-6731
ISSN: 2449-6723

Prenatal Cardiology

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abstract:

Original paper

Segmental myocardial displacement and tissue velocity analysis of the right ventricle in hypoplastic left heart syndrome fetuses and controls using-Color Tissue Doppler Imaging (C-TDI)

Oliver Graupner

¹

,

Christian Enzensberger

²

,

Larissa Wieg

³

,

Aline Wolter

²

,

Can Yerebakan

⁴

,

Markus Khalil

⁵

,

Roland Axt-Fliedner

²

Department of Obstetrics and Gynecology, Klinikum rechts der Isar, Technical University of Munich, Germany
Division of Prenatal Medicine, Department of Obstetrics and Gynecology, Justus-Liebig-University and UKGM, Giessen, Germany
Department of Cardiology, Klinikum rechts der Isar, Technical University of Munich, Germany
NCardiovascular Surgery, Children’s National Heart Institute, George Washington University Medical Center, Washington, DC, USA
Department of Paediatric Cardiology, Justus-Liebig-University and UKGM, Giessen, Germany

Prenat Cardio 2017 Jan; 7(1):12-18

Online publish date: 2019/07/16

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AMA

Graupner O, Enzensberger C, Wieg L, et al. Segmental myocardial displacement and tissue velocity analysis of the right ventricle in hypoplastic left heart syndrome fetuses and controls using-Color Tissue Doppler Imaging (C-TDI). Prenatal Cardiology. 2017;(1):12-18.

APA

Graupner, O., Enzensberger, C., Wieg, L., Wolter, A., Yerebakan, C.,  & Khalil, M. et al. (2017). Segmental myocardial displacement and tissue velocity analysis of the right ventricle in hypoplastic left heart syndrome fetuses and controls using-Color Tissue Doppler Imaging (C-TDI). Prenatal Cardiology, (1), 12-18.

Chicago

Graupner, Oliver, Christian Enzensberger, Larissa Wieg, Aline Wolter, Can Yerebakan, Markus Khalil,  and Roland Axt-Fliedner. 2017. "Segmental myocardial displacement and tissue velocity analysis of the right ventricle in hypoplastic left heart syndrome fetuses and controls using-Color Tissue Doppler Imaging (C-TDI)". Prenatal Cardiology  (1): 12-18.

Harvard

Graupner, O., Enzensberger, C., Wieg, L., Wolter, A., Yerebakan, C., Khalil, M.,  and Axt-Fliedner, R. (2017). Segmental myocardial displacement and tissue velocity analysis of the right ventricle in hypoplastic left heart syndrome fetuses and controls using-Color Tissue Doppler Imaging (C-TDI). Prenatal Cardiology, (1), pp.12-18.

MLA

Graupner, Oliver et al. "Segmental myocardial displacement and tissue velocity analysis of the right ventricle in hypoplastic left heart syndrome fetuses and controls using-Color Tissue Doppler Imaging (C-TDI)." Prenatal Cardiology, no. 1, 2017, pp. 12-18.

Vancouver

Graupner O, Enzensberger C, Wieg L, Wolter A, Yerebakan C, Khalil M et al. Segmental myocardial displacement and tissue velocity analysis of the right ventricle in hypoplastic left heart syndrome fetuses and controls using-Color Tissue Doppler Imaging (C-TDI). Prenatal Cardiology. 2017;(1):12-18.

Introduction
The long-term outcome of patients with HLHS (hypoplastic left heart syndrome) is mainly determined by right ventricular function. Our study examines, whether there are differences in segmental right ventricular myocardial displacement and tissue velocities of fetuses with HLHS compared to healthy fetuses during gestation.

Material and methods
A prospective study was conducted including 20 fetuses with HLHS and 20 gestational age matched controls. c-TDI (colour tissue Doppler imaging) derived systolic and diastolic velocities as well as myocardial displacement were assessed in three different locations of the right ventricle (RV). A ROI (region of interest) was placed in the basal, middle and apical part of the myocardium. Possible changes of c-TDI indices in the course of pregnancy and between the three different segments were investigated in both groups.

Results
HLHS fetuses showed significantly lower e' velocities measured in the basal and middle part of the RV compared to healthy controls (p < 0.05). Basal displacement showed significantly lower values in HLHS fetuses compared to controls. In control fetuses but not in HLHS fetuses there was a significant increase of basal diastolic velocities and displacement in the course of pregnancy. According to myocardial velocities and displacement values there was a significant decrease from the base of the fetal heart to the apex pointed in both groups.

Conclusions
An altered right ventricular myocardial function in HLHS fetuses within different myocardial segments could be demonstrated. An apicobasal gradient with higher velocity and displacement values in the basal part of RV myocardium could be found in both groups. The technique may be of value in the prenatal assessment of myocardial function, however its role as a monitoring tool and outcome predictor needs to be defined.

keywords:

Segmental myocardial displacement and tissue velocity analysis of the right ventricle in hypoplastic left heart syndrome fetuses and controls using-Color Tissue Doppler Imaging (C-TDI)

Oliver Graupner 1 , Christian Enzensberger 2 , Larissa Wieg 3 , Aline Wolter 2 , Can Yerebakan 4 , Markus Khalil 5 , Roland Axt-Fliedner 2

fetal echocardiography, color tissue Doppler imaging, c-TDI, hypoplastic left heart syndrome, fetal cardiac function

Oliver Graupner

¹

,

Christian Enzensberger

²

,

Larissa Wieg

³

,

Aline Wolter

²

,

Can Yerebakan

⁴

,

Markus Khalil

⁵

,

Roland Axt-Fliedner

²