Selected metabolic aspects of elastin and collagen fiber proteolysis in diseases of the respiratory system 
– the significance of α1 antitrypsin deficiency

Agata Dżeljilji; Wojciech Rokicki; Krzysztof Karuś

doi:10.5114/kitp.2016.62614

eISSN: 1897-4252
ISSN: 1731-5530

Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery

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abstract:

Selected metabolic aspects of elastin and collagen fiber proteolysis in diseases of the respiratory system – the significance of α1 antitrypsin deficiency

Agata Dżeljilji

,

Wojciech Rokicki

,

Krzysztof Karuś

Kardiochirurgia i Torakochirurgia Polska 2016; 13 (3): 242-247

DOI: https://doi.org/10.5114/kitp.2016.62614

Online publish date: 2016/09/30

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AMA

Dżeljilji A, Rokicki W, Karuś K. Selected metabolic aspects of elastin and collagen fiber proteolysis in diseases of the respiratory system 
– the significance of α1 antitrypsin deficiency. Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery. 2016;13(3):242-247. doi:10.5114/kitp.2016.62614.

APA

Dżeljilji, A., Rokicki, W.,  & Karuś, K. (2016). Selected metabolic aspects of elastin and collagen fiber proteolysis in diseases of the respiratory system 
– the significance of α1 antitrypsin deficiency. Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery, 13(3), 242-247. https://doi.org/10.5114/kitp.2016.62614

Chicago

Dżeljilji, Agata, Wojciech Rokicki,  and Krzysztof Karuś. 2016. "Selected metabolic aspects of elastin and collagen fiber proteolysis in diseases of the respiratory system 
– the significance of α1 antitrypsin deficiency". Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery 13 (3): 242-247. doi:10.5114/kitp.2016.62614.

Harvard

Dżeljilji, A., Rokicki, W.,  and Karuś, K. (2016). Selected metabolic aspects of elastin and collagen fiber proteolysis in diseases of the respiratory system 
– the significance of α1 antitrypsin deficiency. Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery, 13(3), pp.242-247. https://doi.org/10.5114/kitp.2016.62614

MLA

Dżeljilji, Agata et al. "Selected metabolic aspects of elastin and collagen fiber proteolysis in diseases of the respiratory system 
– the significance of α1 antitrypsin deficiency." Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery, vol. 13, no. 3, 2016, pp. 242-247. doi:10.5114/kitp.2016.62614.

Vancouver

Dżeljilji A, Rokicki W, Karuś K. Selected metabolic aspects of elastin and collagen fiber proteolysis in diseases of the respiratory system 
– the significance of α1 antitrypsin deficiency. Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery. 2016;13(3):242-247. doi:10.5114/kitp.2016.62614.

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The process of elastin and collagen fiber destruction was presented based on the example of the changes taking place in the course of chronic obstructive pulmonary disease and primary spontaneous pneumothorax. In 1963, when analyzing patients with α1 antitrypsin deficiency, Dr Laurell and Dr Eriksson hypothesized that elastolysis plays a role in the pathogenesis of emphysema, which marked the beginning of studies aimed at analyzing this process. The present work concerns new scientific reports regarding the hypothesis. The most important risk factors include protease-antiprotease imbalance and α1 antitrypsin protein deficiency.

keywords:

Selected metabolic aspects of elastin and collagen fiber proteolysis in diseases of the respiratory system – the significance of α1 antitrypsin deficiency

Agata Dżeljilji , Wojciech Rokicki , Krzysztof Karuś

α1 antitrypsin, protease-antiprotease imbalance

Agata Dżeljilji

,

Wojciech Rokicki

,

Krzysztof Karuś