eISSN: 1897-4252
ISSN: 1731-5530
Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery
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4/2019
vol. 16
 
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abstract:
Original paper

Sensitivity and prognostic value of thyroid transcription factor-1 and napsin A in primary adenocarcinoma of the lung

Patryk Kraiński
1
,
Piotr J. Skrzypczak
2
,
Katarzyna Iwanik
1
,
Monika Rozmiarek
2
,
Agnieszka Górna
3
,
Andrzej Kluk
1
,
Paweł Kosikowski
1
,
Maciej Bryl
4
,
Mariusz Kasprzyk
2
,
Aldona Woźniak
1

  1. Department of Thoracic Surgery, Wielkopolska Center of Pulmonology and Thoracic Surgery, Poznan University of Medical Sciences, Poznan, Poland
  2. Department of Clinical Pathology, Heliodor Święcicki Clinical Hospital of Poznan University of Medical Sciences, Poznan, Poland
  3. Department of Clinical Oncology, Wielkopolska Centre for Pulmonology and Thoracic Surgery, Poznan, Poland
  4. Department of Bioinformatics and Computational Biology, Poznan University of Medical Sciences, Heliodor Święcicki Clinical Hospital of Poznan University of Medical Sciences, Poznan, Poland
Kardiochir Torakochir Pol 2019; 16 (4): 180-185
DOI: https://doi.org/10.5114/kitp.2019.91387
Online publish date: 2020/01/15
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Introduction
Lung cancer has been the most common cause of cancer deaths in the past few decades worldwide. In the differentiation of the histopathological types, two basic markers are currently used, which are napsin A and thyroid transcription factor-1 (TTF-1).

Aim
To assess the sensitivity of TTF-1, napsin A and combined use of both markers in detecting primary lung adenocarcinoma. The second aim was to examine the role of TTF-1 and napsin A both alone and in combination as prognostic markers.

Material and methods
In the course of the study, patients’ data were collected and histological specimens were evaluated using TTF-1 and napsin A as cancer markers.

Results
The sensitivities for TTF-1 and napsin A when used separately were 74.58% and 49.15% respectively. When a panel of both TTF-1 and napsin A was used the sensitivity increased to 79.17% as 38 out of 48 cases were positive for either or both of the immunohistochemical markers. The results for 1-, 3-, 4-year survival data were 87.9%, 70.7 %, 58.6%, with TTF-1 positive patients having better survival.

Conclusions
We have shown that both TTF-1 and napsin A are sensitive markers of primary lung adenocarcinoma with TTF-1 being more sensitive. Sensitivity increases when both markers are used in combination.

keywords:

TTF-1, napsin A, adenocarcinoma, prognostic value
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