Sentinel lymph node mapping in endometrial cancer to reduce surgical morbidity: always, sometimes, or never

Angelos Daniilidis; Chrysoula Margioula-Siarkou; Georgia Margioula-Siarkou; Panagiotis Papandreou; Alexios Papanikolaou; Konstantinos Dinas; Stamatios Petousis

doi:10.5114/pm.2022.119862

eISSN: 2299-0038
ISSN: 1643-8876

Menopause Review/Przegląd Menopauzalny

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3/2022
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abstract:

Review paper

Sentinel lymph node mapping in endometrial cancer to reduce surgical morbidity: always, sometimes, or never

Angelos Daniilidis

¹

,

Chrysoula Margioula-Siarkou

¹

,

Georgia Margioula-Siarkou

¹

,

Panagiotis Papandreou

¹

,

Alexios Papanikolaou

¹

,

Konstantinos Dinas

¹

,

Stamatios Petousis

¹

2nd Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, Thessaloniki, Greece

Menopause Rev 2022; 21(3): 207-213

DOI: https://doi.org/10.5114/pm.2022.119862

Online publish date: 2022/10/01

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AMA

Daniilidis A, Margioula-Siarkou C, Margioula-Siarkou G, et al. Sentinel lymph node mapping in endometrial cancer to reduce surgical morbidity: always, sometimes, or never. Menopause Review/Przegląd Menopauzalny. 2022;21(3):207-213. doi:10.5114/pm.2022.119862.

APA

Daniilidis, A., Margioula-Siarkou, C., Margioula-Siarkou, G., Papandreou, P., Papanikolaou, A.,  & Dinas, K. et al. (2022). Sentinel lymph node mapping in endometrial cancer to reduce surgical morbidity: always, sometimes, or never. Menopause Review/Przegląd Menopauzalny, 21(3), 207-213. https://doi.org/10.5114/pm.2022.119862

Chicago

Daniilidis, Angelos, Chrysoula Margioula-Siarkou, Georgia Margioula-Siarkou, Panagiotis Papandreou, Alexios Papanikolaou, Konstantinos Dinas,  and Stamatios Petousis. 2022. "Sentinel lymph node mapping in endometrial cancer to reduce surgical morbidity: always, sometimes, or never". Menopause Review/Przegląd Menopauzalny 21 (3): 207-213. doi:10.5114/pm.2022.119862.

Harvard

Daniilidis, A., Margioula-Siarkou, C., Margioula-Siarkou, G., Papandreou, P., Papanikolaou, A., Dinas, K.,  and Petousis, S. (2022). Sentinel lymph node mapping in endometrial cancer to reduce surgical morbidity: always, sometimes, or never. Menopause Review/Przegląd Menopauzalny, 21(3), pp.207-213. https://doi.org/10.5114/pm.2022.119862

MLA

Daniilidis, Angelos et al. "Sentinel lymph node mapping in endometrial cancer to reduce surgical morbidity: always, sometimes, or never." Menopause Review/Przegląd Menopauzalny, vol. 21, no. 3, 2022, pp. 207-213. doi:10.5114/pm.2022.119862.

Vancouver

Daniilidis A, Margioula-Siarkou C, Margioula-Siarkou G, Papandreou P, Papanikolaou A, Dinas K et al. Sentinel lymph node mapping in endometrial cancer to reduce surgical morbidity: always, sometimes, or never. Menopause Review/Przegląd Menopauzalny. 2022;21(3):207-213. doi:10.5114/pm.2022.119862.

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Introduction
Surgical staging of nodal status is of utmost significance to determine the stage of endometrial cancer and construct a targeted treatment plan. Systematic lymphadenectomy has for years been the procedure of choice for staging purposes, enabling thorough assessment of lymph nodes. Nevertheless, it is associated with increased morbidity and severe postoperative complications. In an attempt to avoid the disadvantages of lymphadenectomy, the use of sentinel lymph node (SLN) biopsy has been examined as an alternative staging procedure. The purpose of the present review is to summarize and provide up-to-date evidence about the role of SLN biopsy in the staging and management of endometrial cancer cases in the terms of optimal technique, efficacy, safety, and postoperative morbidity, as an alternative approach to regional lymphadenectomy.

Material and methods
A thorough literature search was conducted in MEDLINE and SCOPUS to identify recent primary research and previous review articles that explore the use of SLN mapping as a staging procedure in patients with endometrial cancer.

Results
There is increasing evidence that SLN mapping is efficient in identifying metastatic nodal disease without compromising oncological safety, achieving comparable or even superior detection rates to those of lymphadenectomy, when optimal technique and careful intraoperative nodal assessment are applied.

Conclusions
Sentinel lymph node mapping can safely replace lymphadenectomy as an acceptable alternative staging method for endometrial cancer; however, future research might further strengthen this suggestion by resolving potential areas of doubt and debate, especially for high-risk endometrial cancer cases.

keywords:

Sentinel lymph node mapping in endometrial cancer to reduce surgical morbidity: always, sometimes, or never

Angelos Daniilidis 1 , Chrysoula Margioula-Siarkou 1 , Georgia Margioula-Siarkou 1 , Panagiotis Papandreou 1 , Alexios Papanikolaou 1 , Konstantinos Dinas 1 , Stamatios Petousis 1

endometrial cancer, staging, nodal status, sentinel lymph node biopsy, lymphadenectomy

Angelos Daniilidis

¹

,

Chrysoula Margioula-Siarkou

¹

,

Georgia Margioula-Siarkou

¹

,

Panagiotis Papandreou

¹

,

Alexios Papanikolaou

¹

,

Konstantinos Dinas

¹

,

Stamatios Petousis

¹