Serrated polyps of the colorectum: histological classification and clinical significance

Janina Orłowska

eISSN: 2084-9869
ISSN: 1233-9687

Polish Journal of Pathology

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1/2010
vol. 61

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abstract:

Serrated polyps of the colorectum: histological classification and clinical significance

Janina Orłowska

Pol J Pathol 2010; 1: 8-22

Online publish date: 2010/05/12

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Serrated polyps of the colorectum are heterogeneous lesions, a subset of which is now regarded as the precursor of colorectal cancer with DNA microsatellite instability. The serrated pathway encompassing hyperplastic aberrant crypt foci, hyperplastic polyps, sessile serrated polyps (adenomas), mixed polyps, and traditional serrated adenomas, with a meticulous review of their up-to-date histological classifications, is presented. Some remarks concerning genetics of serrated polyps and the mechanism leading to carcinoma development are also included.

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Serrated polyps of the colorectum: histological classification and clinical significance

Janina Orłowska

serrated polyps, hyperplastic polyp, sessile serrated polyp, serrated adenoma