Serum 8-OHdG and HIF-1 levels: do they affect the development of malignancy  	in patients with hypoactive thyroid nodules?

Harman Ece; Erdogan Mehmet; Biray Avci Cigir; Dodurga Yavuz; Karadeniz Muammer; Gunduz Cumhur; Harman Mustafa; Cetinkalp Sevki; Saygili Fusun; Ozgen Ahmet Gokhan

doi:10.5114/wo.2013.33774

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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1/2013
vol. 17

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abstract:

Original paper

Serum 8-OHdG and HIF-1 levels: do they affect the development of malignancy in patients with hypoactive thyroid nodules?

Harman Ece

,

Erdogan Mehmet

,

Biray Avci Cigir

,

Dodurga Yavuz

,

Karadeniz Muammer

,

Gunduz Cumhur

,

Harman Mustafa

,

Cetinkalp Sevki

,

Saygili Fusun

,

Ozgen Ahmet Gokhan

Wspolczesna Onkol 2013; 17 (1): 51–57

DOI: https://doi.org/10.5114/wo.2013.33774

Online publish date: 2013/03/15

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AMA

Ece H, Mehmet E, Cigir B, et al. Serum 8-OHdG and HIF-1 levels: do they affect the development of malignancy  	in patients with hypoactive thyroid nodules?. Contemporary Oncology/Współczesna Onkologia. 2013;17(1):51-57. doi:10.5114/wo.2013.33774.

APA

Ece, H., Mehmet, E., Cigir, B., Yavuz, D., Muammer, K.,  & Cumhur, G. et al. (2013). Serum 8-OHdG and HIF-1 levels: do they affect the development of malignancy  	in patients with hypoactive thyroid nodules?. Contemporary Oncology/Współczesna Onkologia, 17(1), 51-57. https://doi.org/10.5114/wo.2013.33774

Chicago

Ece, Harman, Erdogan Mehmet, Biray Avci Cigir, Dodurga Yavuz, Karadeniz Muammer, Gunduz Cumhur,  and Harman Mustafa et al. 2013. "Serum 8-OHdG and HIF-1 levels: do they affect the development of malignancy  	in patients with hypoactive thyroid nodules?". Contemporary Oncology/Współczesna Onkologia 17 (1): 51-57. doi:10.5114/wo.2013.33774.

Harvard

Ece, H., Mehmet, E., Cigir, B., Yavuz, D., Muammer, K., Cumhur, G., Mustafa, H., Sevki, C., Fusun, S.,  and Gokhan, O. (2013). Serum 8-OHdG and HIF-1 levels: do they affect the development of malignancy  	in patients with hypoactive thyroid nodules?. Contemporary Oncology/Współczesna Onkologia, 17(1), pp.51-57. https://doi.org/10.5114/wo.2013.33774

MLA

Ece, Harman et al. "Serum 8-OHdG and HIF-1 levels: do they affect the development of malignancy  	in patients with hypoactive thyroid nodules?." Contemporary Oncology/Współczesna Onkologia, vol. 17, no. 1, 2013, pp. 51-57. doi:10.5114/wo.2013.33774.

Vancouver

Ece H, Mehmet E, Cigir B, Yavuz D, Muammer K, Cumhur G et al. Serum 8-OHdG and HIF-1 levels: do they affect the development of malignancy  	in patients with hypoactive thyroid nodules?. Contemporary Oncology/Współczesna Onkologia. 2013;17(1):51-57. doi:10.5114/wo.2013.33774.

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Aim of the study: This study aimed to evaluate 8-OHdG and hypoxia-inducible factor 1α (HIF-1α) levels in patients with hypoactive thyroid nodules (toxic multi-nodular goiter, Graves’ disease, and Hashimoto’s thyroiditis), as these parameters may be related to oxidative stress and the pathogenesis of cancer.

Material and methods: The study included patients diagnosed with Graves’ disease (n = 20), toxic multinodular goiter (n = 20), and Hashimoto thyroiditis (n = 20), and 20 healthy controls. HIF-1αα levels were measured in blood samples and 8-OHdG levels were measured in urine – both via ELISA.

Results: HIF-1α and 8-OHdG levels were significantly higher in the patient groups than in the control group (p < 0.05).

In the Hashimoto’s thyroiditis patients a correlation was observed between 8-OHdG and thyroglobulin antibodies (p = 0.03). A significant relation was found between 8-OHdG and HIF-1α in the patient group (p < 0.01). Carcinoma was detected in 7 of 43 female patients, but not in any of the male patients. No difference was observed in 8-OHdG or HIF-1α levels between the patients with and without papillary carcinoma (p > 0.05). There was no significant difference in 8-OHdG or HIF-1α levels between the patients with biopsy results that were benign, malignant, and non-diagnostic (p > 0.05).

Conclusions: Serum HIF-1α and urine 8-OHdG levels were significantly higher in the patients with thyroid diseases; however, a relationship with cancer was not observed.

keywords:

Serum 8-OHdG and HIF-1 levels: do they affect the development of malignancy in patients with hypoactive thyroid nodules?

Harman Ece , Erdogan Mehmet , Biray Avci Cigir , Dodurga Yavuz , Karadeniz Muammer , Gunduz Cumhur , Harman Mustafa , Cetinkalp Sevki , Saygili Fusun , Ozgen Ahmet Gokhan

hypoactive thyroid nodule, 8-OHdG, HIF-1α

Harman Ece

,

Erdogan Mehmet

,

Biray Avci Cigir

,

Dodurga Yavuz

,

Karadeniz Muammer

,

Gunduz Cumhur

,

Harman Mustafa

,

Cetinkalp Sevki

,

Saygili Fusun

,

Ozgen Ahmet Gokhan