Serum amyloid A – an acute-phase protein involved in systemic sclerosis pathogenesis?

Anna Lis-Święty; Małgorzata Widuchowska; Dominika Wcisło-Dziadecka; Ligia Brzezińska-Wcisło; Eugeniusz J. Kucharz

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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5/2012
vol. 99

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abstract:

Review paper

Serum amyloid A – an acute-phase protein involved in systemic sclerosis pathogenesis?

Anna Lis-Święty

,

Małgorzata Widuchowska

,

Dominika Wcisło-Dziadecka

,

Ligia Brzezińska-Wcisło

,

Eugeniusz J. Kucharz

Przegl Dermatol 2012, 99, 632–636

Online publish date: 2012/10/27

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Serum amyloid A (SAA) is a protein contributing to deposition of amyloid in tissues. Secondary amyloidosis develops as a result of a long-standing inflammatory reaction caused by infection or inflammatory disorders in a number of rheumatic diseases such as rheumatoid arthritis, juvenile rheumatoid arthritis and ankylosing spondylitis. Amyloidosis is rarely a complication of systemic sclerosis (SSc), a disease with a relatively low systemic inflammatory compound. Serum amyloid A is also an acute phase protein, which plays a role in the pathogenesis of autoimmune diseases, atherosclerosis and tumours. In this article particular attention is paid to the potential role of SAA in pathological processes in SSc.

keywords:

Serum amyloid A – an acute-phase protein involved in systemic sclerosis pathogenesis?

Anna Lis-Święty , Małgorzata Widuchowska , Dominika Wcisło-Dziadecka , Ligia Brzezińska-Wcisło , Eugeniusz J. Kucharz

systemic sclerosis, amyloidosis, acute-phase response

Anna Lis-Święty

,

Małgorzata Widuchowska

,

Dominika Wcisło-Dziadecka

,

Ligia Brzezińska-Wcisło

,

Eugeniusz J. Kucharz