eISSN: 2299-0038
ISSN: 1643-8876
Menopause Review/Przegląd Menopauzalny
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1/2019
vol. 18
 
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abstract:
Original paper

Serum concentrations of CCL20/MIP-3alpha in women with endometriosis

Grzegorz Jabłoński
1
,
Bogna Sobkiewicz
1
,
Marcin Kaczmarek
1
,
Adrian Krygier
2
,
Jan Bieńkiewicz
1
,
Andrzej Malinowski
1

  1. Department of Surgical, Endoscopic Gynecology and Oncology, Polish Mother’s Memorial Hospital – Research Institute, Łodz, Poland
  2. Oxidative Stress Laboratory of the Center of Medical Laboratory Diagnostics and Screening, Polish Mother’s Memorial Hospital – Research Institute, Łodz, Poland
Menopause Rev 2019; 18(1): 9-14
DOI: https://doi.org/10.5114/pm.2019.84151
Online publish date: 2019/04/09
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Introduction
Endometriosis is a chronic disease defined by the presence of uterine mucosa outside the uterine cavity. Abnormal levels of cytokines, growth factors, adhesion molecules and metalloproteinases have been found in patients with endometriosis. A review of the literature revealed no papers on CCL20 serum levels in women with endometriosis.

Material and methods
The study included 32 women who underwent laparoscopy in the Polish Mother’s Memorial Hospital-Research Institute, Lodz, Poland. Patients were divided into 2 groups: the study and control group. The study group was divided into three subgroups according to endometriosis form. Twenty patients were included in the study group and 12 patients acted as controls. CCL20 concentrations value were determined using a quantitative sandwich ELISA kit (R&D Systems). Results were statistically analyzed by SPSS STATISTICS 24.0.0 software. A significance level of 0.05 was used.

Results
The mean serum level of CCL20 in the study group was 7.4 pg/ml. In controls the mean value was 10.95 pg/ml. The concentration of CCL20 was statistically significantly lower in the study group than in controls (p = 0.004). Within the study group the highest values were reported in patients with endometrial ovarian cysts (8.55 pg/ml), intermediate in the DIE subgroup (8.24 pg/ml) and the lowest in patients with peritoneal endometriosis (6.74 pg/ml). Differences between subgroups were not statistically significant (p = 0.385).

Conclusions
Our study revealed statistically significantly decreased CCL20 serum levels in women with endometriosis. No significant differences of CCL20 serum levels between patients with different forms of endometriosis were observed.

keywords:

endometriosis, chemokines, cytokines
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