Serum ghrelin levels in patients with Behcet’s disease

Ilker Erden; Haydar Uçak; Betül Demir; Demet Cicek; Selma Bakar Dertlioğlu; Suleyman Aydin; Savas Ozturk

doi:10.5114/ada.2016.63884

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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6/2016
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abstract:

Original paper

Serum ghrelin levels in patients with Behcet’s disease

Ilker Erden

,

Haydar Uçak

,

Betül Demir

,

Demet Cicek

,

Selma Bakar Dertlioğlu

,

Suleyman Aydin

,

Savas Ozturk

Adv Dermatol Allergol 2016; XXXIII (6): 450-456

DOI: https://doi.org/10.5114/ada.2016.63884

Online publish date: 2016/12/02

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Introduction: Behcet’s disease (BD) is a chronic, relapsing, systemic vasculitis of unknown etiology.

Aim: To measure serum ghrelin levels in BD patients and healthy controls and to investigate its association with metabolic syndrome (MetS).

Material and methods: Thirty BD patients and 30 healthy individuals were enrolled in the study. Ghrelin levels were measured in blood samples using ELISA.

Results: The mean serum ghrelin level in BD patients (28.57 ±14.04) was significantly lower compared to healthy controls (40.72 ±23.21) (p = 0.01). The mean serum ghrelin level in BD patients who had MetS (24.18 ±12.73) was lower compared to BD patients who did not have MetS (30.77 ±14.45), but this difference was not significant (p > 0.05).

Conclusions: Ghrelin levels were lower in BD patients compared to healthy controls. There was no association between reduced ghrelin levels and MetS; however, there was a negative correlation between ghrelin levels and disease activity.

keywords:

Serum ghrelin levels in patients with Behcet’s disease

Ilker Erden , Haydar Uçak , Betül Demir , Demet Cicek , Selma Bakar Dertlioğlu , Suleyman Aydin , Savas Ozturk

Behcet’s disease, ghrelin, metabolic syndrome, insulin resistance

Ilker Erden

,

Haydar Uçak

,

Betül Demir

,

Demet Cicek

,

Selma Bakar Dertlioğlu

,

Suleyman Aydin

,

Savas Ozturk