Serum levels of inflammasome pathway factors in clinically isolated syndrome and multiple sclerosis patients: a pilot study

Yusuf Tamam; Hande Yüceer; Berna Düzel; Melis Şen; Canan Ulusoy; Erdem Tuzun

doi:10.5114/ceji.2020.96877

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

2/2020
vol. 45

Send email

Copy url:

abstract:

Short communication

Serum levels of inflammasome pathway factors in clinically isolated syndrome and multiple sclerosis patients: a pilot study

Yusuf Tamam

¹

,

Hande Yüceer

²

,

Berna Düzel

¹

,

Melis Şen

²

,

Canan Ulusoy

²

,

Erdem Tuzun

²

Department of Neurology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey
Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey

Cent Eur J Immunol 2020; 45 (2): 237-240

DOI: https://doi.org/10.5114/ceji.2020.96877

Online publish date: 2020/07/09

View full text Get citation

PlumX metrics:

Pathogenic roles of nuclear factor kB (NF-kB) pathway and NLRP3 inflammasome complex factors are involved in multiple sclerosis (MS) development. Activation of the NF-kB, NLRP3, and caspase-1 cascade results in production of proinflammatory cytokines that lead to stimulation of macrophages, lymphocytes, and glial cells. Although increased levels of inflammasome complex factors are observed in MS, contribution of inflammasome pathway to conversion from clinically isolated syndrome (CIS) to relapsing remitting MS (RRMS) has been scarcely investigated. To examine predictive value of inflammasome factors in CIS-MS conversion, levels of NLRP3, caspase-1, and NFkB are measured by ELISA in sera of age-gender matched CIS (n = 18; 8 converting, 10 non-converting) and RRMS (n = 23) patients. CIS and RRMS patients have comparable serum levels of NLRP3, caspase-1, and NFkB. Similarly, no statistically significant difference can be found among converting and nonconverting CIS patients by means of inflammasome complex factor levels. Inflammasome factors are presumably overexpressed at early stages of MS. Therefore, they are unlikely to be used as biomarkers to predict CIS-MS conversion.

keywords:

Serum levels of inflammasome pathway factors in clinically isolated syndrome and multiple sclerosis patients: a pilot study

Yusuf Tamam 1 , Hande Yüceer 2 , Berna Düzel 1 , Melis Şen 2 , Canan Ulusoy 2 , Erdem Tuzun 2

multiple sclerosis, clinically isolated syndrome, neuroinflammation, NLRP3, caspase-1, NFkB

Yusuf Tamam

¹

,

Hande Yüceer

²

,

Berna Düzel

¹

,

Melis Şen

²

,

Canan Ulusoy

²

,

Erdem Tuzun

²