Severe Darier’s disease in a 39-year-old patient

Dorota Kozłowska; Teresa Reduta; Joanna Bacharewicz-Szczerbicka; Iwona Flisiak

doi:10.5114/dr.2018.80843

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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6/2018
vol. 105

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abstract:

Case report

Severe Darier’s disease in a 39-year-old patient

Dorota Kozłowska

,

Teresa Reduta

,

Joanna Bacharewicz-Szczerbicka

,

Iwona Flisiak

Dermatol Rev/Przegl Dermatol 2018, 105, 738–745

DOI: https://doi.org/10.5114/dr.2018.80843

Online publish date: 2019/01/04

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Introduction
Darier’s disease is a rare genodermatosis inherited in an autosomal dominant manner. Clinically, it manifests with hyperkeratotic papules in seborrhoeic and intertriginous areas as well as involvement of nail plates and mucous membranes. Patients may present with neuropsychiatric comorbidities.

Objective
To present a case of a patient with severe Darier’s disease that was successfully treated with acitretin.

Case report
A 39-year-old man with a 24 year history of Darier’s disease was admitted to the hospital because of an exacerbation of skin lesions. A year earlier he underwent an episode of severe depression. Because of signficant severity of skin lecions, acitretin was introduced with improvement.

Conclusions
Oral retinoids are the first line treatment against severe exacerbations of Darier’s disease. Because of possible development of neuropsychiatric disorders, patients with Darier’s disease should receive psychological and/or psychiatric consultations.

keywords:

Severe Darier’s disease in a 39-year-old patient

Dorota Kozłowska , Teresa Reduta , Joanna Bacharewicz-Szczerbicka , Iwona Flisiak

Darier’s disease, genodermatosis, ATP2A2 gene

Dorota Kozłowska

,

Teresa Reduta

,

Joanna Bacharewicz-Szczerbicka

,

Iwona Flisiak