Sex-related differences in clinical outcomes and quality of life after transcatheter aortic valve implantation for severe aortic stenosis

Maciej Bagienski; Tomasz Tokarek; Agata Wiktorowicz; Artur Dziewierz; Lukasz Rzeszutko; Danuta Sorysz; Pawel Kleczynski; Dariusz Dudek

doi:10.5114/aic.2017.70195

eISSN: 1897-4295
ISSN: 1734-9338

Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej

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Original paper

Sex-related differences in clinical outcomes and quality of life after transcatheter aortic valve implantation for severe aortic stenosis

Maciej Bagienski

,

Tomasz Tokarek

,

Agata Wiktorowicz

,

Artur Dziewierz

,

Lukasz Rzeszutko

,

Danuta Sorysz

,

Pawel Kleczynski

,

Dariusz Dudek

Adv Interv Cardiol 2017; 13, 3 (49): 233–239

DOI: https://doi.org/10.5114/aic.2017.70195

Online publish date: 2017/09/25

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AMA

Bagienski M, Tokarek T, Wiktorowicz A, et al. Sex-related differences in clinical outcomes and quality of life after transcatheter aortic valve implantation for severe aortic stenosis. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. 2017;13(3):233-239. doi:10.5114/aic.2017.70195.

APA

Bagienski, M., Tokarek, T., Wiktorowicz, A., Dziewierz, A., Rzeszutko, L.,  & Sorysz, D. et al. (2017). Sex-related differences in clinical outcomes and quality of life after transcatheter aortic valve implantation for severe aortic stenosis. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej, 13(3), 233-239. https://doi.org/10.5114/aic.2017.70195

Chicago

Bagienski, Maciej, Tomasz Tokarek, Agata Wiktorowicz, Artur Dziewierz, Lukasz Rzeszutko, Danuta Sorysz,  and Pawel Kleczynski et al. 2017. "Sex-related differences in clinical outcomes and quality of life after transcatheter aortic valve implantation for severe aortic stenosis". Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej 13 (3): 233-239. doi:10.5114/aic.2017.70195.

Harvard

Bagienski, M., Tokarek, T., Wiktorowicz, A., Dziewierz, A., Rzeszutko, L., Sorysz, D., Kleczynski, P.,  and Dudek, D. (2017). Sex-related differences in clinical outcomes and quality of life after transcatheter aortic valve implantation for severe aortic stenosis. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej, 13(3), pp.233-239. https://doi.org/10.5114/aic.2017.70195

MLA

Bagienski, Maciej et al. "Sex-related differences in clinical outcomes and quality of life after transcatheter aortic valve implantation for severe aortic stenosis." Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej, vol. 13, no. 3, 2017, pp. 233-239. doi:10.5114/aic.2017.70195.

Vancouver

Bagienski M, Tokarek T, Wiktorowicz A, Dziewierz A, Rzeszutko L, Sorysz D et al. Sex-related differences in clinical outcomes and quality of life after transcatheter aortic valve implantation for severe aortic stenosis. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. 2017;13(3):233-239. doi:10.5114/aic.2017.70195.

Introduction: There are inconsistent data on the sex-related differences in clinical outcomes and quality of life (QoL) after transcatheter aortic valve implantation (TAVI).

Aim: We sought to investigate sex-related differences in procedural, clinical and QoL outcomes of TAVI.

Material and methods: A total of 101 consecutive patients undergoing TAVI were enrolled. Patients were stratified by gender. Baseline characteristics, procedural and long-term clinical outcomes as well as frailty and QoL indices (EQ-5D-3L questionnaire) were compared between women and men.

Results: Women represented 60.4% of the study population. Periprocedural risk measured with the Logistic EuroSCORE and STS scale was similar for women and men. There were no differences in 30-day or 12-month all-cause mortality between groups (women vs. men: 9.8% vs. 12.5%; age-adjusted odds ratio (OR) (95% CI): 1.38 (0.39–4.94); 13.1% vs. 25.0%; age-adjusted OR (95% CI): 2.51 (0.87–7.25)). Men were at higher risk of new onset atrial fibrillation at follow-up (1.6% vs. 17.5%; age-adjusted OR (95% CI): 14.61 (1.68–127.37)). In multivariable Cox regression analysis, a history of stroke/transient ischemic attack (TIA) (hazard ratio (HR)) (95% CI): 3.93 (1.39–11.07) and blood transfusion (HR (95% CI): 2.84 (1.06–7.63)) were identified as independent factors affecting 12-month mortality. No differences in QoL parameters were noted.

Conclusions: The TAVI can be considered as an effective and safe treatment in high-risk patients with severe aortic stenosis, regardless of gender.

keywords:

Sex-related differences in clinical outcomes and quality of life after transcatheter aortic valve implantation for severe aortic stenosis

Maciej Bagienski , Tomasz Tokarek , Agata Wiktorowicz , Artur Dziewierz , Lukasz Rzeszutko , Danuta Sorysz , Pawel Kleczynski , Dariusz Dudek

outcomes, gender, aortic stenosis, transcatheter aortic valve implantation

Maciej Bagienski

,

Tomasz Tokarek

,

Agata Wiktorowicz

,

Artur Dziewierz

,

Lukasz Rzeszutko

,

Danuta Sorysz

,

Pawel Kleczynski

,

Dariusz Dudek