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eISSN: 2449-6731
ISSN: 2449-6723
Prenatal Cardiology
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abstract:
Original paper

Short-and long-term growth as a function of abnormal Doppler flow in growth-restricted fetuses

John W. Ross
1
,
Alexandria Betz
1
,
Michael J. Paglia
1
,
Wen Feng
1
,
A. George Neubert
1
,
A. Dhanya Mackeen
1

  1. Geisinger, Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine (1), and Biostatistics Core (2), 100 N. Academy Ave, Danville, Pennsylvania, 17821 USA
Prenat Cardio 2018 Jan; 8(1):76-79
DOI: https://doi.org/10.5114/pcard.2018.86685
Online publish date: 2019/07/16
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Objectives
To evaluate short- and long-term growth in fetuses with growth restriction (FGR) and elevated umbilical artery Doppler (UAD) systolic/diastolic (S/D) ratios.

Methods
In this prospective observational study, two UAD waveforms were obtained from each umbilical artery weekly and were classified as normal or abnormal. Fetal growth was assessed every 3 weeks. Short-term growth was calculated from the first visit with elevated ratios until next growth assessment. Results were grouped by number of initial elevated S/D ratios (maximum, 4). Long-term growth was evaluated by change in estimated fetal weight from diagnosis of FGR to birth weight. Fetuses were grouped by average number of elevated S/D ratios and compared to a reference population of growth restricted fetuses with normal testing.

Results
Of 241 fetuses evaluated, 105 demonstrated elevated S/D ratios. Short-term growth was impaired when fetuses had elevated S/D ratios. Long-term growth was affected when the average number of elevated S/D ratios was ≥1 per visit. Progressive 3 or 4 growth delay was noted as the average number of abnormal S/D ratios increased.

Conclusions
Short- and long-term fetal growth are affected by elevated UAD S/D ratios. Fetuses with more abnormal values initially and those with a higher average of elevated values over pregnancy demonstrate decreased growth.

keywords:

fetal growth restriction, umbilical artery systolic/diastolic ratios, estimated fetal weight, long-term growth, short-term growth
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