Short-term prognosis of childhood hepatoblastoma in relation to ERCC1 C118T single nucleotide polymorphism and VEGF expression

Yuan Wen; Weiling Zhang; Yi Zhang; Huimin Hu; Jing Li; Dongsheng Huang

doi:10.5114/pjp.2019.93134

eISSN: 2084-9869
ISSN: 1233-9687

Polish Journal of Pathology

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4/2019
vol. 70

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abstract:

Original paper

Short-term prognosis of childhood hepatoblastoma in relation to ERCC1 C118T single nucleotide polymorphism and VEGF expression

Yuan Wen

¹

,

Weiling Zhang

¹

,

Yi Zhang

¹

,

Huimin Hu

¹

,

Jing Li

¹

,

Dongsheng Huang

¹

Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing, China

Pol J Pat hol 2019; 70 (4): 304-310

DOI: https://doi.org/10.5114/pjp.2019.93134

Online publish date: 2020/03/06

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To evaluate the short-term prognosis of pediatric hepatoblastoma (HB) in relation to excision repair cross-complementation gene 1 (ERCC1) C118T single nucleotide polymorphism (SNP) and VEGF expression.

ERCC1 C118T SNP and VEGF expression were detected and investigated in 31 children with HB undergoing platinum-based chemotherapy, to analyze their relationship with short-term pediatric HB prognosis.

CC (38.7%; 12/31), CT (35.5%; 11/31), and TT (25.8%; 8/31) ERCC1 C118T mutation types were identified. The Kaplan-Meier survival curve analysis showed that the CC group had a better short-term prognosis than the CT + TT group (p = 0.010). VEGF was overexpressed in 14 cases (45.2%) and underexpressed in 17 cases (54.8%). The Kaplan-Meier survival curve analysis showed that the high VEGF expression group showed poorer short-term prognosis than the lower VEGF expression group (p = 0.004).

In this study, ERCC1 C118T SNP in children with HB was mainly found to be mutant type CT + TT. Compared to wild type CC, children with the mutant type CT + TT exhibited better treatment efficacy and remission with platinum-based chemotherapy as well as better survival rates. Moreover, the short-term prognosis of children with low VEGF expression was better than in those with high expression.

keywords:

Short-term prognosis of childhood hepatoblastoma in relation to ERCC1 C118T single nucleotide polymorphism and VEGF expression

Yuan Wen 1 , Weiling Zhang 1 , Yi Zhang 1 , Huimin Hu 1 , Jing Li 1 , Dongsheng Huang 1

ERCC1 gene, single nucleotide polymorphism, VEGF, hepatoblastoma, prognosis, platinum drugs

Yuan Wen

¹

,

Weiling Zhang

¹

,

Yi Zhang

¹

,

Huimin Hu

¹

,

Jing Li

¹

,

Dongsheng Huang

¹