Short-term stent coverage of second-generation zotarolimus-eluting durable polymer stents: Onyx one-month optical coherence tomography study

Tomasz Roleder; Elvin Kedhi; Balazs Berta; Pawel Gasior; Wojciech Wanha; Magda Roleder; Joanna Fluder; Grzegorz Smolka; Andrzej Ochala; Wojciech Wojakowski

doi:10.5114/aic.2019.86009

eISSN: 1897-4295
ISSN: 1734-9338

Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej

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2/2019
vol. 15

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abstract:

Original paper

Short-term stent coverage of second-generation zotarolimus-eluting durable polymer stents: Onyx one-month optical coherence tomography study

Tomasz Roleder

¹

,

Elvin Kedhi

²

,

Balazs Berta

²

,

Pawel Gasior

¹

,

Wojciech Wanha

¹

,

Magda Roleder

¹

,

Joanna Fluder

¹

,

Grzegorz Smolka

¹

,

Andrzej Ochala

¹

,

Wojciech Wojakowski

¹

Department of Cardiology and Structural Heart Diseases, 3rd Division of Cardiology, Medical University of Silesia, Katowice, Poland
Isala Haartcentrum, Zwolle, Netherlands

Adv Interv Cardiol 2019; 15, 2 (56): 143–150

DOI: https://doi.org/10.5114/aic.2019.86009

Online publish date: 2019/06/26

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AMA

Roleder T, Kedhi E, Berta B, et al. Short-term stent coverage of second-generation zotarolimus-eluting durable polymer stents: Onyx one-month optical coherence tomography study. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. 2019;15(2):143-150. doi:10.5114/aic.2019.86009.

APA

Roleder, T., Kedhi, E., Berta, B., Gasior, P., Wanha, W.,  & Roleder, M. et al. (2019). Short-term stent coverage of second-generation zotarolimus-eluting durable polymer stents: Onyx one-month optical coherence tomography study. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej, 15(2), 143-150. https://doi.org/10.5114/aic.2019.86009

Chicago

Roleder, Tomasz, Elvin Kedhi, Balazs Berta, Pawel Gasior, Wojciech Wanha, Magda Roleder,  and Joanna Fluder et al. 2019. "Short-term stent coverage of second-generation zotarolimus-eluting durable polymer stents: Onyx one-month optical coherence tomography study". Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej 15 (2): 143-150. doi:10.5114/aic.2019.86009.

Harvard

Roleder, T., Kedhi, E., Berta, B., Gasior, P., Wanha, W., Roleder, M., Fluder, J., Smolka, G., Ochala, A.,  and Wojakowski, W. (2019). Short-term stent coverage of second-generation zotarolimus-eluting durable polymer stents: Onyx one-month optical coherence tomography study. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej, 15(2), pp.143-150. https://doi.org/10.5114/aic.2019.86009

MLA

Roleder, Tomasz et al. "Short-term stent coverage of second-generation zotarolimus-eluting durable polymer stents: Onyx one-month optical coherence tomography study." Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej, vol. 15, no. 2, 2019, pp. 143-150. doi:10.5114/aic.2019.86009.

Vancouver

Roleder T, Kedhi E, Berta B, Gasior P, Wanha W, Roleder M et al. Short-term stent coverage of second-generation zotarolimus-eluting durable polymer stents: Onyx one-month optical coherence tomography study. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. 2019;15(2):143-150. doi:10.5114/aic.2019.86009.

Introduction
To date the early strut coverage with the second-generation durable-polymer ONYX zotarolimus-eluting stent (O-ZES) is unknown.

Aim
Optical coherence tomography (OCT) assessed the strut coverage of O-ZES at thirty-day follow-up.

Material and methods
OCT was performed after implantation and at 1-month follow-up in 15 patients treated with O-ZES.

Results
Mean patient age was 67 ±7 years (73% males). The clinical presentation consisted of acute coronary syndromes (n = 13) and stable coronary disease (n = 2). Four (26%) patients had diabetes. OCT analysis was performed at baseline and 1-month follow-up in all stents. 378 cross-sections with 3582 struts were assessed at baseline and 3661 at follow-up. At follow-up, 88% struts were covered by tissue with a median thickness 37.91 µm (IQR: 22.32–64.15). Median in-stent area obstruction by neointima was 2.64% (IQR: 1.70–4.84). From the total stent covered area, 92.3% showed complete strut coverage. Homogeneous tissue was observed in 74% of cases. There were no differences in minimal lumen area (5.07 ±1.08 mm2 vs. 4.81 ±0.94 mm2, p = 0.125) or minimal stent area (4.95 ±1.22 mm2 vs. 4.92 ±0.99 mm2) at baseline and at follow-up. There were no differences in the rate of strut malapposition (4.3% vs. 5.7%, p = 0.417). For all stents, malapposition volume was 47.9 mm3 at baseline and 51.7 mm3 at follow-up, giving the late acquired stent malapposition volume of 3.8 mm3.

Conclusions
The second-generation durable polymer O-ZES showed favorable vessel healing at 30-day OCT follow-up.

keywords:

Short-term stent coverage of second-generation zotarolimus-eluting durable polymer stents: Onyx one-month optical coherence tomography study

Tomasz Roleder 1 , Elvin Kedhi 2 , Balazs Berta 2 , Pawel Gasior 1 , Wojciech Wanha 1 , Magda Roleder 1 , Joanna Fluder 1 , Grzegorz Smolka 1 , Andrzej Ochala 1 , Wojciech Wojakowski 1

zotarolimus-eluting stent, vessel healing, optical coherence tomography, 1-month follow-up

Tomasz Roleder

¹

,

Elvin Kedhi

²

,

Balazs Berta

²

,

Pawel Gasior

¹

,

Wojciech Wanha

¹

,

Magda Roleder

¹

,

Joanna Fluder

¹

,

Grzegorz Smolka

¹

,

Andrzej Ochala

¹

,

Wojciech Wojakowski

¹