eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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3/2020
vol. 45
 
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abstract:
Clinical immunology

Single nucleotide polymorphism of transforming growth factor-β1 and interleukin-6 as risk factors for ovarian cancer

Amira Ben Ahmed
1
,
Sabrina Zidi
1
,
Wassim Almawi
2
,
Ezzeddine Ghazouani
3
,
Amel Mezlini
4
,
Besma Yacoubi Loueslati
1
,
Mouna Stayoussef
1

  1. Department of Biology, Faculty of Sciences of Tunis, Laboratory of Mycology, Pathologies and Biomarkers: LR16ES05, El Manar University, Tunis, Tunisia
  2. College of Health Sciences, Abu Dhabi University, United Arab Emirates
  3. Laboratory of Immunology, Military Hospital of Tunis, Tunis, Tunisia
  4. Salah Azeiz Oncology Institute, Tunis, Tunisia
Cent Eur J Immunol 2020; 45 (3): 267-275
DOI: https://doi.org/10.5114/ceji.2020.101242
Online publish date: 2020/11/01
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Introduction
We investigated the association between common variants in TGF-1, IL-6 and the risk of ovarian cancer (OC) in Tunisian patients and control women.

Material, methods and results
Study subjects comprised 71 OC cases and 74 control women. Genotyping of TGF-1 and IL-6 SNPs was done by real-time PCR. No differences were noted in the minor allele frequencies of the three TGF-1 SNPs between OC patients and controls. However, marked differences in the distribution of TGF-1 rs1800469 genotypes were seen between OC cases and controls (p < 0.001), with TGF-1 rs1800469 heterozygous (C/T) genotype being negatively associated with OC (OR [95% CI] = 0.24 [0.15-0.58]). The allelic and genotypic distributions at IL-6 polymorphisms showed a positive association between minor allele (G) at IL-6 rs1880242 variant (p = 0.0275; R [95% CI] = 1.88 [1.03-3.46]) and the occurrence of OC. In fact, the presence of T allele [G/T + T/T] decrease the risk of OC (p = 0.021; OR [95% CI] = 0.38 [0.17-0.88]). In addition, the Haploview analysis demonstrated high linkage disequilibrium (LD) between IL-6 SNPs and eight-locus haplotype analysis identified that GGAGGGGA and GGAGGGTA haplotypes are positively associated with OC risk. A negative association was shown between IL-6 haplotype (TGGGCCTA) and OC occurrence.

Conclusions
Our results suggest that TGF-1 rs1800469, IL-6 rs1880242 variants and IL-6 haplotype (TGGGCCTA) have protective roles of OC risk. IL-6 haplotypes (GGAGGGGA and GGAGGGTA) increase OC susceptibility among Tunisian women.

keywords:

TGF-1, IL-6, gene polymorphism, ovarian cancer, haplotypes, Tunisian women
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