Sinusoidal obstruction syndrome in a paediatric patient with acute lymphoblastic leukaemia after completion of reinduction therapy according to ALL Intercontinental Berlin-Frankfurt-Münster 2009

Dorota Pawlik-Gwozdecka; Ninela Irga-Jaworska; Marek Tomaszewski; Elżbieta Adamkiewicz-Drożyńska

doi:10.5114/wo.2018.82646

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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vol. 22

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abstract:

Case report

Sinusoidal obstruction syndrome in a paediatric patient with acute lymphoblastic leukaemia after completion of reinduction therapy according to ALL Intercontinental Berlin-Frankfurt-Münster 2009

Dorota Pawlik-Gwozdecka

,

Ninela Irga-Jaworska

,

Marek Tomaszewski

,

Elżbieta Adamkiewicz-Drożyńska

Contemp Oncol (Pozn) 2018; 22 (4): 266-269

DOI: https://doi.org/10.5114/wo.2018.82646

Online publish date: 2018/12/31

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AMA

Pawlik-Gwozdecka D, Irga-Jaworska N, Tomaszewski M, Adamkiewicz-Drożyńska E. Sinusoidal obstruction syndrome in a paediatric patient with acute lymphoblastic leukaemia after completion of reinduction therapy according to ALL Intercontinental Berlin-Frankfurt-Münster 2009. Contemporary Oncology/Współczesna Onkologia. 2018;22(4):266-269. doi:10.5114/wo.2018.82646.

APA

Pawlik-Gwozdecka, D., Irga-Jaworska, N., Tomaszewski, M.,  & Adamkiewicz-Drożyńska, E. (2018). Sinusoidal obstruction syndrome in a paediatric patient with acute lymphoblastic leukaemia after completion of reinduction therapy according to ALL Intercontinental Berlin-Frankfurt-Münster 2009. Contemporary Oncology/Współczesna Onkologia, 22(4), 266-269. https://doi.org/10.5114/wo.2018.82646

Chicago

Pawlik-Gwozdecka, Dorota, Ninela Irga-Jaworska, Marek Tomaszewski,  and Elżbieta Adamkiewicz-Drożyńska. 2018. "Sinusoidal obstruction syndrome in a paediatric patient with acute lymphoblastic leukaemia after completion of reinduction therapy according to ALL Intercontinental Berlin-Frankfurt-Münster 2009". Contemporary Oncology/Współczesna Onkologia 22 (4): 266-269. doi:10.5114/wo.2018.82646.

Harvard

Pawlik-Gwozdecka, D., Irga-Jaworska, N., Tomaszewski, M.,  and Adamkiewicz-Drożyńska, E. (2018). Sinusoidal obstruction syndrome in a paediatric patient with acute lymphoblastic leukaemia after completion of reinduction therapy according to ALL Intercontinental Berlin-Frankfurt-Münster 2009. Contemporary Oncology/Współczesna Onkologia, 22(4), pp.266-269. https://doi.org/10.5114/wo.2018.82646

MLA

Pawlik-Gwozdecka, Dorota et al. "Sinusoidal obstruction syndrome in a paediatric patient with acute lymphoblastic leukaemia after completion of reinduction therapy according to ALL Intercontinental Berlin-Frankfurt-Münster 2009." Contemporary Oncology/Współczesna Onkologia, vol. 22, no. 4, 2018, pp. 266-269. doi:10.5114/wo.2018.82646.

Vancouver

Pawlik-Gwozdecka D, Irga-Jaworska N, Tomaszewski M, Adamkiewicz-Drożyńska E. Sinusoidal obstruction syndrome in a paediatric patient with acute lymphoblastic leukaemia after completion of reinduction therapy according to ALL Intercontinental Berlin-Frankfurt-Münster 2009. Contemporary Oncology/Współczesna Onkologia. 2018;22(4):266-269. doi:10.5114/wo.2018.82646.

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Sinusoidal obstruction syndrome (SOS), also termed veno-occlusive disease (VOD) of the liver, is a well-known complication of haematopoietic stem cell transplantation (HSCT) both in children and adults. In the medical literature there are occasional reports of SOS in patients receiving conventional chemotherapy. In children with solid tumours this entity occurs during treatment of nephroblastoma, rhabdomyosarcoma, and medulloblastoma. In the late 1990s SOS was quite often observed as the complication of oral 6-thioguanine (6-TG) in patients suffering from acute lymphoblastic leukaemia (ALL), who received 6-TG throughout maintenance. In current protocols, the syndrome has become uncommon because treatment with 6-TG is limited to two weeks of oral therapy. Here, we report a case of a nine-year-old boy with ALL, who developed sinusoidal obstruction syndrome shortly after completing the reinduction block of chemotherapy (cyclophosphamide, cytarabine, thioguanine) according to the ALL Intercontinental Berlin-Frankfurt-Münster 2009 (ALL IC BFM 2009) treatment protocol.

keywords:

Sinusoidal obstruction syndrome in a paediatric patient with acute lymphoblastic leukaemia after completion of reinduction therapy according to ALL Intercontinental Berlin-Frankfurt-Münster 2009

Dorota Pawlik-Gwozdecka , Ninela Irga-Jaworska , Marek Tomaszewski , Elżbieta Adamkiewicz-Drożyńska

acute lymphoblastic leukaemia, veno-occlusive disease, sinusoidal obstruction syndrome, children

Dorota Pawlik-Gwozdecka

,

Ninela Irga-Jaworska

,

Marek Tomaszewski

,

Elżbieta Adamkiewicz-Drożyńska