Skin microvascular circulation is not affected by diabetes duration in young patients with non-complicated type 1 diabetes mellitus

Melanie Wielicka; Jolanta Neubauer-Geryk; Agnieszka Brandt-Varma; Małgorzata Myśliwiec; Leszek Bieniaszewski

doi:10.5114/pedm.2019.89641

eISSN: 2083-8441
ISSN: 2081-237X

Pediatric Endocrinology Diabetes and Metabolism

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abstract:

Original paper

Skin microvascular circulation is not affected by diabetes duration in young patients with non-complicated type 1 diabetes mellitus

Melanie Wielicka

¹

,

Jolanta Neubauer-Geryk

²

,

Agnieszka Brandt-Varma

³

,

Małgorzata Myśliwiec

³

,

Leszek Bieniaszewski

²

Medical University of Gdansk, Gdansk, Poland
Clinical Physiology Unit, Medical Simulation Centre, Medical University of Gdansk, Gdansk, Poland
Department of Pediatrics, Diabetology and Endocrinology, Medical University of Gdansk, Gdansk, Poland

Pediatr Endocrinol Diabetes Metab 2019; 25 (4): 183-187

DOI: https://doi.org/10.5114/pedm.2019.89641

Online publish date: 2019/12/30

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AMA

Wielicka M, Neubauer-Geryk J, Brandt-Varma A, Myśliwiec M, Bieniaszewski L. Skin microvascular circulation is not affected by diabetes duration in young patients with non-complicated type 1 diabetes mellitus. Pediatric Endocrinology Diabetes and Metabolism. 2019;25(4):183-187. doi:10.5114/pedm.2019.89641.

APA

Wielicka, M., Neubauer-Geryk, J., Brandt-Varma, A., Myśliwiec, M.,  & Bieniaszewski, L. (2019). Skin microvascular circulation is not affected by diabetes duration in young patients with non-complicated type 1 diabetes mellitus. Pediatric Endocrinology Diabetes and Metabolism, 25(4), 183-187. https://doi.org/10.5114/pedm.2019.89641

Chicago

Wielicka, Melanie, Jolanta Neubauer-Geryk, Agnieszka Brandt-Varma, Małgorzata Myśliwiec,  and Leszek Bieniaszewski. 2019. "Skin microvascular circulation is not affected by diabetes duration in young patients with non-complicated type 1 diabetes mellitus". Pediatric Endocrinology Diabetes and Metabolism 25 (4): 183-187. doi:10.5114/pedm.2019.89641.

Harvard

Wielicka, M., Neubauer-Geryk, J., Brandt-Varma, A., Myśliwiec, M.,  and Bieniaszewski, L. (2019). Skin microvascular circulation is not affected by diabetes duration in young patients with non-complicated type 1 diabetes mellitus. Pediatric Endocrinology Diabetes and Metabolism, 25(4), pp.183-187. https://doi.org/10.5114/pedm.2019.89641

MLA

Wielicka, Melanie et al. "Skin microvascular circulation is not affected by diabetes duration in young patients with non-complicated type 1 diabetes mellitus." Pediatric Endocrinology Diabetes and Metabolism, vol. 25, no. 4, 2019, pp. 183-187. doi:10.5114/pedm.2019.89641.

Vancouver

Wielicka M, Neubauer-Geryk J, Brandt-Varma A, Myśliwiec M, Bieniaszewski L. Skin microvascular circulation is not affected by diabetes duration in young patients with non-complicated type 1 diabetes mellitus. Pediatric Endocrinology Diabetes and Metabolism. 2019;25(4):183-187. doi:10.5114/pedm.2019.89641.

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Introduction
Skin microcirculation is recognized as an appropriate model to use when investigating the relationship between cardiovascular risk factors and microvascular function. It is currently a matter of debate whether studies on skin microcirculation in young type 1 diabetic patients without existing microangiopathy may be helpful in identifying subjects with impaired endothelial function.

Aim of the study
To evaluate the potential changes in skin microcirculation of patients up age of 18 years using capillaroscopy, post reactive hyperaemia (PORH) and venous occlusion (VO) tests, and to establish the relationship between those changes and disease duration and metabolic control in patients with type 1 diabetes.

Material and methods
Study group consisted of 112 pediatric patients aged 8.4–18.0 years, with a median age of 14.95 years. The median diabetes duration and age at onset were 5 years and 9.6 years, respectively. The median HbA1c in the studied group was 7.6% at the time when the microcirculation was being examined. Capillaroscopy studies were focused on type 1 diabetic patients and employed non-selective stimuli such as the PORH and VO tests. The relative area covered by capillaries (coverage) was measured before the testing and again after the PORH and VO tests.

Results
The analysis revealed that none of the skin microcirculation indices correlated significantly with patient age, diabetes duration or metabolic control.

Conclusions
In young patients with uncomplicated type 1 diabetes mellitus skin microcirculation function is not dependent on age, disease duration or metabolic control.

keywords:

Skin microvascular circulation is not affected by diabetes duration in young patients with non-complicated type 1 diabetes mellitus

Melanie Wielicka 1 , Jolanta Neubauer-Geryk 2 , Agnieszka Brandt-Varma 3 , Małgorzata Myśliwiec 3 , Leszek Bieniaszewski 2

diabetes mellitus type 1, skin microcirculation, capillaroscopy, diabetes duration, metabolic control

Melanie Wielicka

¹

,

Jolanta Neubauer-Geryk

²

,

Agnieszka Brandt-Varma

³

,

Małgorzata Myśliwiec

³

,

Leszek Bieniaszewski

²