eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
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4/2017
vol. 68
 
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abstract:
Case report

Soft tissue metastasis of mediastinal non-functioning paraganglioma with unusual TTF-1 expression: a potential diagnostic pitfall

Michal Benej
,
Iva Zambo
,
Ondrej Bílek
,
Ivan Capov

Pol J Pathol 2017; 68 (4): 354-358
DOI: https://doi.org/10.5114/pjp.2017.73931
Online publish date: 2018/03/06
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Metastatic extra-adrenal paragangliomas are very rare and can represent diagnostic challenges. We report a case of 69-year-old man with a tumor of the right shoulder. Histologic and immunohistochemical examinations confirmed the diagnosis of paraganglioma. Surprisingly, tumor cells were diffusely thyroid transcription factor 1 (TTF-1) positive. Succinate dehydrogenase complex subunit B (SDHB) deficiency has not been detected. Inherited syndromes associated with paragangliomas were ruled out. The primary tumor was identified in the mediastinum. This is the first report of TTF-1 expression in paraganglioma. To avoid misdiagnosis, careful clinical and pathological examination of any tumor with organoid growths pattern is necessary.
keywords:

neuroendocrine tumor, malignant paraganglioma, hereditary syndromes, thyroid transcription factor 1
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