Soluble CD25 as a predictor of hepatocellular carcinoma compared with alpha-fetoprotein

Shaymaa Nafady Abdelfattah; Alaa Farouk Haseeb; Mohammad Mohammad Tawfik; Doaa Mahmoud Khalil; Dina Attia

doi:10.5114/ceh.2019.85165

eISSN: 2449-8238
ISSN: 2392-1099

Clinical and Experimental Hepatology

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abstract:

Original paper

Soluble CD25 as a predictor of hepatocellular carcinoma compared with alpha-fetoprotein

Shaymaa Nafady Abdelfattah

¹

,

Alaa Farouk Haseeb

¹

,

Mohammad Mohammad Tawfik

¹

,

Doaa Mahmoud Khalil

²

,

Dina Attia

¹

Department of Gastroenterology, Hepatology and Endemic Medicine, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt
Public Health and Community Medicine Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt

Clin Exp HEPATOL 2019; 5, 2: 140–146

DOI: https://doi.org/10.5114/ceh.2019.85165

Online publish date: 2019/05/23

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Aim of the study
We aimed to evaluate soluble CD25 (sCD25) as a marker for hepatocellular carcinoma (HCC) diagnosis.

Material and methods
Eighty-eight subjects were enrolled in our study in the years 2017-2018. They were divided into three groups as follows: group 1 – HCC group (n = 44) patients, represented by BCLC stage A (n = 16) patients, stage B (n = 14) patients and stage C (n = 14) patients for each stage. All HCC patients were on top of cirrhosis. Group 2 – group of cirrhotic patients without HCC (n = 32); 50% of them were Child-Turcotte-Pugh class A (n = 16) while class B was represented only by 43.7% (n = 14) of patients. Group 3 – control group (n = 12) of healthy subjects.

Results
The levels of sCD25 and AFP were higher in HCC patients than cirrhotic and control groups without a statistically significant difference between the three groups (p-value > 0.05). For HCC presence, sensitivity and specificity of sCD25 were 86.4% and 29.5% respectively at a cut-off value of 1.1 × 103 pg/ml (AUC = 0.619, p-value = 0.054, PPV = 33.2%, NPV = 68.44%). For early detection of HCC, sCD25 had a sensitivity of 70.5% and a specificity of 30.9% at a cut-off value of 1.575 × 103 pg/ml (AUC = 0.577, p-value = 0.251, PPV = 58.5%, NPV = 43.1%), while the sensitivity and specificity of AFP were 75% and 62.5% respectively at a cut-off value of 9.5 ng/ml (AUC = 0.828, p = 0.000, PPV = 73.4%, NPV = 64.4%) in the same settings.

Conclusions
sCD25 seems to offer no better detection rate of HCC compared to AFP with lower sensitivity and specificity.

keywords:

Soluble CD25 as a predictor of hepatocellular carcinoma compared with alpha-fetoprotein

Shaymaa Nafady Abdelfattah 1 , Alaa Farouk Haseeb 1 , Mohammad Mohammad Tawfik 1 , Doaa Mahmoud Khalil 2 , Dina Attia 1

hepatocellular carcinoma, alpha-fetoprotein, HCC markers, soluble CD25

Shaymaa Nafady Abdelfattah

¹

,

Alaa Farouk Haseeb

¹

,

Mohammad Mohammad Tawfik

¹

,

Doaa Mahmoud Khalil

²

,

Dina Attia

¹