Spontaneous miscarriage/abortion in the first trimester and expectant management – a meta-analysis approach

Anwesa Acharya; Ananya Prabhu; Shivali Negi; Kavya Sharma; Rinshu Dwivedi; Ramesh Athe

doi:10.5114/pm.2023.131307

eISSN: 2299-0038
ISSN: 1643-8876

Menopause Review/Przegląd Menopauzalny

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3/2023
vol. 22

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abstract:

Original paper

Spontaneous miscarriage/abortion in the first trimester and expectant management – a meta-analysis approach

Anwesa Acharya

¹

,

Ananya Prabhu

²

,

Shivali Negi

³

,

Kavya Sharma

³

,

Rinshu Dwivedi

⁴

,

Ramesh Athe

⁵

Department of Computer Science and Engineering, CMR University, Bangalore, India
Department of Public Health Dentistry, Manipal College of Dental Sciences, Manipal, India
Centre for Public Health, Punjab University, Chandigarh, India
Department of Science and Humanities, Indian Institute of Information Technology, Tiruchirappalli, India
Department of Data Science and Intelligent Systems, Indian Institute of Information Technology, Dharwad, India

Menopause Rev 2023; 22(3): 135-141

DOI: https://doi.org/10.5114/pm.2023.131307

Online publish date: 2023/09/20

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Introduction
To determine effectiveness and side effects of expectant care in first-trimester miscarriage. An increase in the spontaneous miscarriage rate and its associated complications exerts a burden on the overall health and quality of life of women. Expectant care in a first-trimester miscarriage has shown success ranging from 75 to 80%. This study was designed to search the literature for information on the clinical safety and effectiveness of expectant management on spontaneous miscarriage during the first trimester.

Material and methods
The review included studies that included women in expectant care for spontaneous miscarriage in the first trimester. Trial studies were recognized through a methodical and organized database search from PubMed, COCHRANE, MEDLINE, Embase, and bibliography from January 2000 until December 2022. The methodological assessment and risk of bias was assessed using the Joanna Briggs Institute criteria.

Results
Eleven studies in systematic review and 7 studies in the meta-analysis were included. The included studies showed a low to moderate risk of bias. The odds of success in expectant intervention were low when compared with surgical intervention (odds ratio – OR: OR: 0.37 [0.28, 0.48]) and medical management (OR: 0.47 [0.36, 0.61]), and the need for surgical evacuation was high (OR: 2.59 [1.88, 3.59])

Conclusions
Future trials should consider women’s opinions and the effect on quality of life along with clinical consequences, to provide improved suggestions on the efficiency and adverse effects.

keywords:

Spontaneous miscarriage/abortion in the first trimester and expectant management – a meta-analysis approach

Anwesa Acharya 1 , Ananya Prabhu 2 , Shivali Negi 3 , Kavya Sharma 3 , Rinshu Dwivedi 4 , Ramesh Athe 5

meta-analysis, miscarriage, expectant management, systematic review, first-trimester

Anwesa Acharya

¹

,

Ananya Prabhu

²

,

Shivali Negi

³

,

Kavya Sharma

³

,

Rinshu Dwivedi

⁴

,

Ramesh Athe

⁵