Spontaneous pathological complete regression of high-grade triple-negative breast cancer with axillary metastasis

Gábor Cserni; Orsolya Serfozo; Éva Ambrózay; László Markó; László Krenács

doi:10.5114/pjp.2019.87105

eISSN: 2084-9869
ISSN: 1233-9687

Polish Journal of Pathology

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2/2019
vol. 70

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abstract:

Case report

Spontaneous pathological complete regression of high-grade triple-negative breast cancer with axillary metastasis

Gábor Cserni

¹

,

Orsolya Serfozo

²

,

Éva Ambrózay

²

,

László Markó

³

,

László Krenács

⁴

Institute of Pathology, University of Szeged, Szeged, Hungary
Breast Imaging Unit, Mamma Rt, Kecskemét, Hungary
Departments of Oncology and Surgery, Bács-Kiskun County Teaching Hospital, Kecskemét, Hungary
Laboratory of Tumour Pathology and Molecular Diagnostics, Szeged, Hungary

Pol J Pathol 2019; 70 (2): 139-143

DOI: https://doi.org/10.5114/pjp.2019.87105

Online publish date: 2019/09/04

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We report on a breast carcinoma with medullary features diagnosed by core needle biopsy in a 72-year-old woman. Both the primary tumour and its fine needle aspiration-proven, rapidly growing axillary metastasis regressed completely in less than 2 months, by the time surgery was performed. The biopsy of the primary tumour demonstrated a dense stromal infiltrate of CD8+/granzyme B+ activated cytotoxic T-cells suggestive of a robust antitumour immune response. Paradoxically, both tumour cells and tumour infiltrating immune cells demonstrated a diffuse PD-L1 expression, revealing that antitumour immune response has the ability to spontaneously overcome inhibitory mechanisms induced by cancerous growth.

keywords:

Spontaneous pathological complete regression of high-grade triple-negative breast cancer with axillary metastasis

Gábor Cserni 1 , Orsolya Serfozo 2 , Éva Ambrózay 2 , László Markó 3 , László Krenács 4

PD-L1, spontaneous regression, tumour-infiltrating lymphocytes, triple-negative breast cancer

Gábor Cserni

¹

,

Orsolya Serfozo

²

,

Éva Ambrózay

²

,

László Markó

³

,

László Krenács

⁴