eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
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6/1999
vol. 3
 
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abstract:

Structure and functions of ErbB (HER) receptors

Bogdan Falkiewicz
,
Krzysztof P. Bielawski
,
Ulf Vogt

Współcz Onkol (1999) 6, 241-243
Online publish date: 2003/08/07
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The paper describes general characteristics, classification and structure of the tyrosine kinase receptor family ErbB (HER). They are encoded by two well-known proto-oncogenes erbB-1 (HER1, egfr) and erbB-2 (HER2, neu), as well as two genes of probably oncogenic function, namely erbB-3 (HER3) and erbB-4 (HER4). Receptors’ ligands, scheme of dimerisation, signal transduction and function were reviewed. Mechanisms leading to excessive activity of the receptor kinases (probably related to their oncogenic potential) were also denoted.
keywords:

oncogenes, tyrosine kinases, ErbB (HER) receptors

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