Study of the association between a MICA gene polymorphism and cholangiocarcinoma in Egyptian patients

Adel Abdel-Rahman; Moshera Farag; Mary Naguib; Eman Abdelsameea; Hamed Abdel-Bary

doi:10.5114/ceh.2022.122293

eISSN: 2449-8238
ISSN: 2392-1099

Clinical and Experimental Hepatology

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4/2022
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abstract:

Original paper

Study of the association between a MICA gene polymorphism and cholangiocarcinoma in Egyptian patients

Adel A.-H. Abdel-Rahman

¹

,

Moshera Abdallah Hassan Farag

¹

,

Mary Naguib

²

,

Eman Abdelsameea

²

,

Hamed M. Abdel-Bary

¹

Faculty of Science, Menoufia University, Shebein El-Kom, Egypt
National Liver Institute, Shebein El-Kom, Egypt

Clin Exp HEPATOL 2022; 8, 4: 293-299

DOI: https://doi.org/10.5114/ceh.2022.122293

Online publish date: 2022/12/28

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Introduction
An inflammatory environment is the common pathway for the development of cholangiocarcinoma (CCA). The natural killer group 2D receptor (NKG2D), an activating receptor for NK cells, is a potent immune axis in the antitumor and antimicrobial immune response through its binding to NKG2D ligands (NKG2DLs). NKG2DLs are normally absent or poorly expressed in most cells; conversely, they are upregulated in stressed cells. We studied the rs2596542 polymorphism located upstream of the MICA gene, which encodes an NKG2DL, in patients with CCA as a marker for early disease detection and a possible therapeutic target.

Material and methods
A case-control study was conducted on 40 patients with CCA and 45 healthy individuals (as controls). After routine examination, the rs2596542 polymorphism of the MICA gene was investigated using real-time PCR.

Results
We found that a TT homozygous genotype was significantly predominant in patients with CCA (p = 0.039), with the T allele being dominantly distributed in CCA (p = 0.007). High levels of CA19-9 were significantly associated with the TT genotype in the patients. However, we did not detect significant differences in rs2596542C/T genotype and allele distribution between patients with CCA with cirrhosis and those without cirrhosis (p > 0.05).

Conclusions
The MICA rs2596542 polymorphism may affect the susceptibility to CCA, but not its progression. The TT genotype could be used as a potential diagnostic marker for CCA and triggering the MICA pathway could be a promising therapeutic target.

keywords:

Study of the association between a MICA gene polymorphism and cholangiocarcinoma in Egyptian patients

Adel A.-H. Abdel-Rahman 1 , Moshera Abdallah Hassan Farag 1 , Mary Naguib 2 , Eman Abdelsameea 2 , Hamed M. Abdel-Bary 1

cholangiocarcinoma, Egyptian patients, epidemiology

Adel A.-H. Abdel-Rahman

¹

,

Moshera Abdallah Hassan Farag

¹

,

Mary Naguib

²

,

Eman Abdelsameea

²

,

Hamed M. Abdel-Bary

¹