Successful desensitization with 5-fluorouracil in a patient who developed anaphylaxis after 5-fluorouracil infusion

Mehmet Erdem Çakmak; Nida Oztop; Osman Ozan Yeğit

doi:10.5114/pja.2024.142143

eISSN: 2391-6052
ISSN: 2353-3854

Alergologia Polska - Polish Journal of Allergology

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abstract:

Case report

Successful desensitization with 5-fluorouracil in a patient who developed anaphylaxis after 5-fluorouracil infusion

Mehmet Erdem Çakmak

¹

,

Nida Oztop

¹

,

Osman Ozan Yeğit

¹

Department of Allergy and Clinical Immunology, Başakşehir Çam and Sakura City Hospital, Istanbul, Turkey

Alergologia Polska – Polish Journal of Allergology 2024; 11, 3

DOI: https://doi.org/10.5114/pja.2024.142143

Online publish date: 2024/08/12

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5-Fluorouracil (5-FU) is a chemotherapeutic agent widely used in the treatment of gastrointestinal tract, skin and breast cancers. Hypersensitivity reactions may occur due to the use of chemotherapeutic drugs. The underlying mechanisms of hypersensitivity reactions to chemotherapeutic drugs are not clear and depend on the drugs. Hypersensitivity reactions may develop with both immunological and non-immunological mechanisms. 5-FU infusion chemotherapy may cause early types of life-threatening hypersensitivity reactions. If 5-FU infusion chemotherapy must be administered after an allergic reaction, it should be administered with a desensitization protocol. Life-threatening hypersensitivity reactions to 5-FU are rare in the literature. The case is here presented of a patient with metastatic gastric cancer who developed anaphylaxis during systemic 5-FU administration and was successfully desensitized to 5-FU.

keywords:

Successful desensitization with 5-fluorouracil in a patient who developed anaphylaxis after 5-fluorouracil infusion

Mehmet Erdem Çakmak 1 , Nida Oztop 1 , Osman Ozan Yeğit 1

5-fluorouracil, anaphylaxis, drug allergy, chemotherapy, rapid desensitization

Mehmet Erdem Çakmak

¹

,

Nida Oztop

¹

,

Osman Ozan Yeğit

¹