Sulodexide – unrealized potential in dermatology

Dorota Krasowska; Beata Polkowska-Pruszyńska; Anna Michalak-Stoma

doi:10.5114/dr.2019.83444

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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1/2019
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abstract:

Review paper

Sulodexide – unrealized potential in dermatology

Dorota Krasowska

¹

,

Beata Polkowska-Pruszyńska

¹

,

Anna Michalak-Stoma

¹

Department of Dermatology, Venereology, and Paediatric Dermatology, Medical University of Lublin, Poland

Dermatol Rev/Przegl Dermatol 2019, 106, 52–70

DOI: https://doi.org/10.5114/dr.2019.83444

Online publish date: 2019/03/19

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Sulodexide is a highly purified mixture of glycosaminoglycans composed of fast mobility heparin (80%) and dermatan sulfate (20%). Glycosaminoglycans constitute a group of heteropolysaccharides consisting of repeating disaccharide units, which contain amino sugar combined with uronic acid or a hexose. Glycosaminoglycans build glycocalyx covering endothelium of blood vessels, and thus, play an important role in vascular homeostasis. Multi-directional activity of sulodexide including antithrombotic, fibrinolytic, anti-aggregation, anti-inflammatory, anti-proliferative, and anti-oxidative qualities, as well as a high safety profile have allowed using the drug in numerous entities. Advantageous results of sulodexide therapy are observed in diseases involving endothelial damage, prothrombotic or inflammatory states. Thanks to its pleiotropic effects, sulodexide can be also applied in treatment of skin diseases.

keywords:

Sulodexide – unrealized potential in dermatology

Dorota Krasowska 1 , Beata Polkowska-Pruszyńska 1 , Anna Michalak-Stoma 1

sulodexide, therapy, skin diseases

Dorota Krasowska

¹

,

Beata Polkowska-Pruszyńska

¹

,

Anna Michalak-Stoma

¹