Suppressor genes as molecular markers of colorectal cancer – a review of the latest reports

Agnieszka Piechowska; Monika Wawszczak; Anna Cedro; Stanisław Głuszek

doi:10.5114/ms.2020.94087

eISSN: 2300-6722
ISSN: 1899-1874

Medical Studies/Studia Medyczne

Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

1/2020
vol. 36

Send email

Copy url:

abstract:

Review paper

Suppressor genes as molecular markers of colorectal cancer – a review of the latest reports

Agnieszka M. Piechowska

¹

,

Monika Wawszczak

¹

,

Anna Cedro

²

,

Stanisław Głuszek

^{1, 3}

Department of Surgical Medicine with the Laboratory of Medical Genetics,, Institute of Medical Sciences, Jan Kochanowski University, Kielce, Poland
Department of Cardiovascular Disease Prevention and Pharmacology, Institute of Health Sciences, Jan Kochanowski University, Kielce, Poland
Department of Clinic General Oncological and Endocrinological Surgery, Regional Hospital, Kielce, Poland

Medical Studies/Studia Medyczne 2020; 36 (1): 35–45

DOI: https://doi.org/10.5114/ms.2020.94087

Online publish date: 2020/03/31

View full text Get citation

PlumX metrics:

Suppressor gene research is one of the main current trends in modern cancer research. Oncogenesis, including colorectal cancer (CRC), is a process strictly dependent on the proper functioning of the suppressor genes and their proteins. The molecular genetic studies of hereditary cases and sporadic forms of cancer conducted for several years have revealed that a significant feature of the occurrence and progression of neoplastic changes is silencing of the expression of tissue-specific suppressor genes. Restoring the proper activity of the respective suppressor proteins plays a key role in anti-cancer prevention and gives hope for the development of effective personalised therapy. This review presents the latest reports on the molecular mechanisms regulating the expression, activity, and function of suppressor genes, which were silenced in tissues and cell lines of colorectal cancer, and restoration of their correct expression inhibited the proliferation and invasion of CRC cells.

keywords:

Suppressor genes as molecular markers of colorectal cancer – a review of the latest reports

Agnieszka M. Piechowska 1 , Monika Wawszczak 1 , Anna Cedro 2 , Stanisław Głuszek 1, 3

colorectal cancer, biomarkers, signalling pathways, suppressor genes

Agnieszka M. Piechowska

¹

,

Monika Wawszczak

¹

,

Anna Cedro

²

,

Stanisław Głuszek

^{1, 3}