Surface markers of cancer stem-like cells of ovarian cancer and their clinical relevance

Aleksandra Klemba; J. Karolina Purzycka-Olewiecka; Gabriel Wcisło; Anna M. Czarnecka; Sławomir Lewicki; Bogdan Lesyng; Cezary Szczylik; Claudine Kieda

doi:10.5114/wo.2018.73885

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

Bieżący numer Archiwum Współczesna Onkologia

NOWOŚĆ

Portal dla onkologów!

www.eonkologia.pl

Wyszukiwanie

1/2018

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Artykuł przeglądowy

Surface markers of cancer stem-like cells of ovarian cancer and their clinical relevance

Aleksandra Klemba

,

J. Karolina Purzycka-Olewiecka

,

Gabriel Wcisło

,

Anna M. Czarnecka

,

Sławomir Lewicki

,

Bogdan Lesyng

,

Cezary Szczylik

,

Claudine Kieda

DOI: https://doi.org/10.5114/wo.2018.73885

Data publikacji online: 2018/03/08

Pełna treść artykułu Pobierz cytowanie

Metryki PlumX:

Cancer stem-like cells (CSLCs) are defined as cancer cells with stem cell characteristics. Although CSLCs constitute no more than a few percent of the tumor mass, they play important roles in cancer chemo-resistance, metastasis and disease recurrence. Ovarian cancer (OC) is considered the most aggressive gynecological malignancy in which the role of CSLCs is of major significance, although it remains to be specified. The studies describing ovarian CSLC phenotype vary in the definition of the molecular pattern of expression of the main markers such as CD133, CD44, CD117, and CD24. Stem-like features of OC have been shown to correlate with the clinical course of the disease and permit diagnosis, prognosis and treatment outcome to be improved. Identification of CSLC markers could provide hallmarks which, related to the chemo-resistance of the disease, will facilitate treatment selection. This review describes recent advances in research on stem-like cell status in OC, mainly focusing on surface markers of CSLCs and their clinical relevance.

Surface markers of cancer stem-like cells of ovarian cancer and their clinical relevance

Aleksandra Klemba , J. Karolina Purzycka-Olewiecka , Gabriel Wcisło , Anna M. Czarnecka , Sławomir Lewicki , Bogdan Lesyng , Cezary Szczylik , Claudine Kieda

Aleksandra Klemba

,

J. Karolina Purzycka-Olewiecka

,

Gabriel Wcisło

,

Anna M. Czarnecka

,

Sławomir Lewicki

,

Bogdan Lesyng

,

Cezary Szczylik

,

Claudine Kieda