Survivin and caspase-3 and PanIN. Disorders of apoptosis
in the process of pancreatic cancer formation

Konrad Zaręba; Justyna Dorf; Kerianne Cummings; Anna Pryczynicz; Katarzyna Guzińska-Ustymowicz; Bogusław Kędra

doi:10.5114/ms.2024.137585

eISSN: 2300-6722
ISSN: 1899-1874

Medical Studies/Studia Medyczne

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abstract:

Original paper

Survivin and caspase-3 and PanIN. Disorders of apoptosis in the process of pancreatic cancer formation

Konrad Zaręba

¹

,

Justyna Dorf

²

,

Kerianne Cummings

³

,

Anna Pryczynicz

⁴

,

Katarzyna Guzińska-Ustymowicz

⁴

,

Bogusław Kędra

¹

2nd Clinical Department of General, Gastroenterological and Oncological Surgery, Medical University of Bialystok, Bialystok, Poland
Department of Clinical Laboratory Diagnostics, Medical University of Bialystok, Bialystok, Poland
Students’ Scientific Association, 2nd Clinical Department of General, Gastroenterological and Oncological Surgery, Medical University of Bialystok, Bialystok, Poland
Department of General Pathomorphology, Medical University of Bialystok, Bialystok, Poland

Medical Studies/Studia Medyczne 2024; 40 (1): 1–7

DOI: https://doi.org/10.5114/ms.2024.137585

Online publish date: 2024/03/28

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Introduction:
It is believed that pancreatic intraepithelial neoplasia is an important element of pancreatic carcinogenesis. Apoptosis is the process of programmed cell death. Survivin is one of the proteins that inhibit apoptosis. Caspase-3 is a cysteine protease, and plays important roles in the process of apoptosis.

Aim of the research:
The authors focus on analyzing the expression of survivin and caspase-3 in unchanged tissue and tissue from PanIN lesions. This study may help to better understand the cause-and-effect chain from low-grade intraepithelial neoplasia to high-grade neoplasia and invasive cancer.

Material and methods:
The study used tissue material obtained from 70 patients operated on at the 2^nd Department of General, Gastroenterological and Oncological Surgery at the Medical University of Bialystok due to pancreatic diseases: adenocarcinoma (38 patients), chronic pancreatitis (23 patients), pancreatic cysts (9 patients). A total of 239 tissue samples were isolated for clinical examination.

Results:
There were statistically significant differences in survivin expression by sex (p < 0.05) and age (p < 0.05). The level of survivin expression was higher in male patients and patients over 60. There were statistically significant differences between the expression levels of survivin as well as caspase-3 depending on the degree of PanIN [PanIN 1A vs PanIN 1b survivin 15% vs. 38.8% (p < 0.05), and caspase-3 17%; vs. 26.9% (p < 0.05). PanIN 2 vs. PaIN3 survivin 62.4% vs. 85.7% (p < 0.05), caspase-3 36.1% vs. 54.3% (p < 0.05)].

Conclusions:
The expression level of survivin and caspase-3 is inextricably linked with the progression of pancreatic intraepithelial neoplasia. The more advanced neoplasia is, the higher is the expression level.

keywords:

Survivin and caspase-3 and PanIN. Disorders of apoptosis in the process of pancreatic cancer formation

Konrad Zaręba 1 , Justyna Dorf 2 , Kerianne Cummings 3 , Anna Pryczynicz 4 , Katarzyna Guzińska-Ustymowicz 4 , Bogusław Kędra 1

caspase-3, PanIN, apoptosis, survivin

Konrad Zaręba

¹

,

Justyna Dorf

²

,

Kerianne Cummings

³

,

Anna Pryczynicz

⁴

,

Katarzyna Guzińska-Ustymowicz

⁴

,

Bogusław Kędra

¹