eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
Current issue Archive Manuscripts accepted About the journal Supplements Addendum Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
3/2007
vol. 11
 
Share:
Share:
abstract:

Vaccinotherapy in renal cell carcinoma

Dariusz W. Kowalczyk

Współczesna Onkologia (2007) vol. 11; 3 (160–166)
Online publish date: 2007/04/26
View full text Get citation
 
Renal cell carcinoma is resistant to classical radiotherapy or chemotherapy. On the other hand these tumors seem to be immunogenic which make them potentially susceptible to immunotherapeutic approaches including anti-cancer vaccines. This article presents an analysis of recent publications on vaccine based treatments of renal cell carcinoma. Through Medline search 41 clinical trials were identified involving 1094 patients. Tested vaccines were composed of tumor cells, tumor lysates, dendritic cells, peptides or heat shock proteins. Clinical response data were presented for 657 patients with advanced (stage IV) cancer. Objective response was observed in about 27.4% of these patients: 20 patients showed complete response (CR) (3.0%), 36 partial response (PR) (5.5%), 10 mixed response (MR) (1.5%) and 114 had stable disease (SD) (17.4%). It appears that active, vaccine based immunotherapy may induce anti-tumor immune reaction in selected group of patients leading to moderate clinical responses.
keywords:

renal cell carcinoma, kidney cancer, vaccines, immunotherapy, clinical trials

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.