THE EFFECT OF COMBINED ACTION OF TYPES OF LEAD NANOPARTICLES AND STEARATES ON INDICATORS OF THE OXIDATIVE STRESS IN THE BODY OF EXPERIMENTAL ANIMALS

Background
The aim of this work was to determine the effect of the combined action of nanoparticles of stearates and lead on the state of lipid peroxidation, antioxidant defense, and the level of circulating immune complexes in experimental rats.

Material and methods
Experiments were conducted on four groups of white rats. The first (control) and second groups of animals consumed dechlorinated water from the city water supply. The third and fourth groups of animals consumed water, respectively, with the content of sodium stearate and potassium stearate in a dose of 1/250 LD50. After 40 days of drinking the indicated waters, the animals of the second, third, and fourth groups were orally injected with lead nanoparticles at a dose of 1/250 of the LD50.

Results
The combined effect of sodium stearate and lead nanoparticles, potassium stearate, and lead nanoparticles had the character of additive action and potentiation according to most indicators of lipid peroxidation and antioxidant protection. According to the change of the circulating immune complexes indicator in the blood, it had the character of antagonistic action.

Conclusions
Our studies have shown that, in most indicators of lipid peroxidation and antioxidant system, the combined action of lead nanoparticles and stearates had the character of potentiation.