THE EFFECT OF OMEPRAZOLE ON TREATMENT OUTCOMES IN PATIENTS WITH SEVERE TRAUMATIC BRAIN INJURY AND SEPSIS

Oleksandr Oliynyk

doi:10.5114/hpc.2020.98946

eISSN: 2354-0265
ISSN: 2353-6942

Health Problems of Civilization Physical activity: diseases and issues recognized by the WHO

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abstract:

Original paper

THE EFFECT OF OMEPRAZOLE ON TREATMENT OUTCOMES IN PATIENTS WITH SEVERE TRAUMATIC BRAIN INJURY AND SEPSIS

Oleksandr Oliynyk

¹

Department of Medical Rescue, Pope John Paul II State School of Higher Education in Biała Podlaska, Poland

DOI: https://doi.org/10.5114/hpc.2020.98946

Online publish date: 2020/10/20

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Background
The interrelation between omeprazole use and the possibility of developing nosocomial pneumonia, acute kidney damage and Clostridium difficile-induced diarrhea in patients with sepsis requires further study.

Material and methods
200 patients with severe craniocerebral injury that underwent surgery for the pathology and developed sepsis in the postoperative period were examined in a blind, randomized placebo-controlled research study. The patients were divided into two groups. Patients in Group 1, as part of their therapy regimen for sepsis, received a daily dose of 0.2 mg/kg omeprazole as an intravenous infusion; patients in Group 2 received placebo instead of omeprazole, in addition to a similar therapy regimen as Group 1.

Results
Among patients receiving omeprazole, the number of concomitant ventilator-associated pneumonia cases increased by 1.32 times, the number of acute kidney damage cases by 1.33 times and the number of cases of Clostridium difficile toxin secretion with feces by 1.75 times.

Conclusions
The routine use of omeprazole in the management of patients with sepsis may worsen treatment results.

keywords:

THE EFFECT OF OMEPRAZOLE ON TREATMENT OUTCOMES IN PATIENTS WITH SEVERE TRAUMATIC BRAIN INJURY AND SEPSIS

Oleksandr Oliynyk 1

omeprazole, ventilator-associated pneumonia, acute renal injury, sepsis, clostridial infection

Oleksandr Oliynyk

¹