THE INFLUENCE OF COMORBID GASTROENTEROLOGICAL PATHOLOGY WITH EXOCRINE PANCREATIC INSUFFICIENCY ON THE COURSE OF PRIMARY OSTEOARTHRITIS

Background
About 303 million people worldwide suffer from osteoarthritis, creating a global medical problem that affects not only the individual patient but also society as a whole.

Material and methods
304 patients with primary osteoarthritis in comorbidity with diseases of the gastrointestinal tract, accompanied by exocrine pancreatic insufficiency, without exacerbation, were examined.

Results
The level of the WOMAC index scales in the 5th group was higher by 40.89% for pain, 79.74% for stiffness, 35.05% for functional insufficiency, and by 40.02% in total compared with the 1st group; in the 4th group, the level of indicators of the WOMAC index scales was higher by 9.60%, by 17.36%, by 10.01% and 10.40%, respectively; in the 3rd group, an increase of 17.24% was found, by 34.73%, by 19.15% and by 19.10%, respectively; in the 2nd group, there was a higher level of these indicators by 28.44%, by 56.59%, by 26.19%, and by 29 .02%, respectively.

Conclusions
As evidenced by the post hoc analysis of the WOMAC index data obtained for the course of primary osteoarthritis, starting from the highest, it was shown that: type 2 diabetes mellitus ˃ chronic pancreatitis ˃ chronic non-calculous cholecystitis and functional diseases of the gallbladder and biliary tract systems ˃ chronic gastroduodenitis (р˂0.05).