THE ROLE OF PRO-INFLAMMATORY CYTOKINES IN THE GENESIS OF PHYSIOLOGICAL AND PATHOLOGICAL PREGNANCY PREDICTING

Objective: hold concentration determination and study changes in interleukin-1 (IL-1) and interleukin - 6 (IL-6) in pregnant women outside urban areas and in pregnant women living in the city, and to predict the appearance of a possible risk of premature birth.

Material study: Were examined 40 pregnant women who make up the group of 23-27 weeks of gestation who were admitted with threatened preterm labor (20 pregnant women living in the countryside, and 20 pregnant women living in the city), as well as a control group - 20 healthy pregnant women with physiological pregnancy.

Methods: In all patients and control group was performed determining the content of IL - 1 and IL - 6 in serum by enzyme immunoassay (ELISA) using a test system»Vector-Best» (Russia) on an automatic ELISA analyzer «Triturus». Statistical analysis of data was carried out using the method of variation statistics with using STATISTICA 6 (Statsoft, USA)

The results of the study: in determining kontsentratsiyiyi proinflammatory cytokines observed increase in IL-1 and IL-6 in pregnant women living in countryside and cities in the pregnant compared with the control group of pregnant women with physiological pregnancy (probability differences (p <0,05)).

Conclusions: The definition and measurement of proinflammatory cytokines is an opportunity to use the test as early inflammation and mapping the degree of threat of preterm labor. The study of changes in the cytokine brings us to the pathogenic mechanisms of the transition process active infection.