TNF superfamily - mechanisms of action, biologic funtions and therapeutic possibilities

Anna Lubecka-Macura; Maciej Kohut

doi:10.5114/pg.2010.18472

eISSN: 1897-4317
ISSN: 1895-5770

Gastroenterology Review/Przegląd Gastroenterologiczny

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6/2010
vol. 5

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abstract:

Review paper

TNF superfamily - mechanisms of action, biologic funtions and therapeutic possibilities

Anna Lubecka-Macura

,

Maciej Kohut

Przegląd Gastroenterologiczny 2010; 5 (6): 303–309

DOI: https://doi.org/10.5114/pg.2010.18472

Online publish date: 2010/12/08

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We present a brief historical introduction of tumour necrosis factor (TNF). Molecular structure and cellular origins are introduced. The TNF superfamily with its multiple members and variety of functions is summarized. Receptor activity and biological effects of TNF are discussed. Particular attention is drawn to TNF’s influence on neoplasms and inflammatory bowel diseases. Finally, anti-TNF therapies (including biological and small-molecule therapies) are described.

keywords:

TNF superfamily - mechanisms of action, biologic funtions and therapeutic possibilities

Anna Lubecka-Macura , Maciej Kohut

TNF, inflammatory bowel diseases

Anna Lubecka-Macura

,

Maciej Kohut