Taurine mitigates cirrhosis-associated heart injury through mitochondrial-dependent and antioxidative mechanisms

Khadijeh Mousavi; Hossein Niknahad; Amin Ghalamfarsa; Hamidreza Mohammadi; Negar Azarpira; Mohammad Mehdi Ommati; Reza Heidari

doi:10.5114/ceh.2020.99513

eISSN: 2449-8238
ISSN: 2392-1099

Clinical and Experimental Hepatology

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abstract:

Original paper

Taurine mitigates cirrhosis-associated heart injury through mitochondrial-dependent and antioxidative mechanisms

Khadijeh Mousavi

^{1, 2}

,

Hossein Niknahad

^{1, 2}

,

Amin Ghalamfarsa

^{1, 2}

,

Hamidreza Mohammadi

^{1, 2}

,

Negar Azarpira

³

,

Mohammad Mehdi Ommati

⁴

,

Reza Heidari

²

Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
College of Life Sciences, Shanxi Agricultural University, Taigu, Shanxi, P.R. China

Clin Exp HEPATOL 2020; 6, 3: 207–219

DOI: https://doi.org/10.5114/ceh.2020.99513

Online publish date: 2020/09/30

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Cirrhosis-induced heart injury and cardiomyopathy is a serious consequence of this disease. It has been shown that bile duct ligated (BDL) animals could serve as an appropriate experimental model to investigate heart tissue injury in cirrhosis. The accumulation of cytotoxic chemicals (e.g., bile acids) could also adversely affect the heart tissue. Oxidative stress and mitochondrial impairment are the most prominent mechanisms of bile acid cytotoxicity. Taurine (Tau) is the most abundant non-protein amino acid in the human body. The cardioprotective effects of this amino acid have repeatedly been investigated. In the current study, it was examined whether mitochondrial dysfunction and oxidative stress are involved in the pathogenesis of cirrhosis-induced heart injury. Rats underwent BDL surgery. BDL animals received Tau (50, 100, and 500 mg/kg, i.p.) for 42 consecutive days. A significant increase in oxidative stress biomarkers was detected in the heart tissue of BDL animals. Moreover, it was found that heart tissue mitochondrial indices of functionality were deteriorated in the BDL group. Tau treatment significantly decreased oxidative stress and improved mitochondrial function in the heart tissue of cirrhotic animals. These data provide clues for the involvement of mitochondrial impairment and oxidative stress in the pathogenesis of heart injury in BDL rats. On the other hand, Tau supplementation could serve as an effective ancillary treatment against BDL-associated heart injury. Mitochondrial regulating and antioxidative properties of Tau might play a fundamental role in its mechanism of protective effects in the heart tissue of BDL animals.

keywords:

Taurine mitigates cirrhosis-associated heart injury through mitochondrial-dependent and antioxidative mechanisms

Khadijeh Mousavi 1, 2 , Hossein Niknahad 1, 2 , Amin Ghalamfarsa 1, 2 , Hamidreza Mohammadi 1, 2 , Negar Azarpira 3 , Mohammad Mehdi Ommati 4 , Reza Heidari 2

amino acid, bioenergetics, cardiomyopathy, cirrhosis, heart failure, mitochondrial impairment

Khadijeh Mousavi

^{1, 2}

,

Hossein Niknahad

^{1, 2}

,

Amin Ghalamfarsa

^{1, 2}

,

Hamidreza Mohammadi

^{1, 2}

,

Negar Azarpira

³

,

Mohammad Mehdi Ommati

⁴

,

Reza Heidari

²