1. Boehncke WH, Schön MP. Psoriasis. Lancet 2015; 386: 983-94.
2.
Alinaghi F, Calov M, Kristensen LE, et al. Prevalence of psoriatic arthritis in patients with psoriasis: a systematic review and meta-analysis of observational and clinical studies. J Am Acad Dermatol 2019; 80: 251-65.e19.
3.
Pathirana D, Ormerod A, Saiag P, et al. European S3-guidelines on the systemic treatment of psoriasis vulgaris. J Eur Acad Dermatol Venereol 2009; 23 Suppl 2: 1-70.
4.
Detmar M, Orfanos CE. Tumor necrosis factor-alpha inhibits cell proliferation and induces class II antigens and cell adhesion molecules in cultured normal human keratinocytes in vitro. Arch Dermatol Res 1990; 282: 238-45.
5.
Austin LM, Ozawa M, Kikuchi T, et al. The majority of epidermal t cells in psoriasis vulgaris lesions can produce type 1 cytokines, interferon-g, interleukin-2, and tumor necrosis factor-a, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations:1 a type 1 differentiation bias is also measured in circulating blood T cells in psoriatic patients. J Investig Dermatol 1999; 113: 752-9.
6.
Chiricozzi A, Suárez-Fariñas M, Fuentes-Duculan J, et al. Increased expression of interleukin-17 pathway genes in nonlesional skin of moderate‐to‐severe psoriasis vulgaris. Br J Dermatol 2016; 174: 136-45.
7.
Brembilla NC, Senra L, Boehncke W-H. The IL-17 family of cytokines in psoriasis: IL-17A and beyond. Front Immunol 2018; 9: 1682.
8.
Yang K, Oak ASW, Elewski BE. Use of IL-23 inhibitors for the treatment of plaque psoriasis and psoriatic arthritis: a comprehensive review. Am J Clin Dermatol 2021; 22: 173-92.
9.
Teng MWL, Bowman EP, McElwee JJ, et al. IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases. Nat Med 2015; 21: 719-29.
10.
Polesie S, Gillstedt M, Sönnergren HH, et al. Methotrexate treatment and risk for cutaneous malignant melanoma: a retrospective comparative registry-based cohort study.
11.
Br J Dermatol 2017; 176: 1492-9.
12.
Stern RS. The risk of melanoma in association with long-term exposure to PUVA. J Am Acad Dermatol 2001; 44: 755-61.
13.
Esse S, Mason KJ, Green AC, Warren RB. Melanoma risk in patients treated with biologic therapy for common inflammatory diseases. JAMA Dermatol 2020; 156: 787-94.
14.
Liu R, Wan Q, Zhao R, et al. Risk of non-melanoma skin cancer with biological therapy in common inflammatory diseases: a systemic review and meta-analysis. Cancer Cell Int 2021; 21: 614.
15.
Krzysztofik M, Brzewski P, Cuber P, et al. Risk of melanoma and non-melanoma skin cancer in patients with psoriasis and psoriatic arthritis treated with targeted therapies: a systematic review and meta-analysis. Pharmaceuticals 2023; 17: 14.
16.
Vignali DAA, Kuchroo VK. IL-12 family cytokines: immunological playmakers. Nat Immunol 2012; 13: 722-8.
17.
Teng MWL, Bowman EP, McElwee JJ, et al. IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases. Nat Med 2015; 21: 719-29.
18.
Subhadarshani S, Yusuf N, Elmets CA. IL-23 and the tumor microenvironment. Adv Exp med Biol 2021; 1290: 89-98.
19.
Tugues S, Burkhard SH, Ohs I, et al. New insights into IL-12-mediated tumor suppression. Cell Death Differ 2015; 22: 237-46.
20.
Nastala CL, Edington HD, McKinney TG, et al. Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production. J Immunol 1994; 153: 1697-706.
21.
Noguchi Y, Jungbluth A, Richards EC, Old LJ. Effect of interleukin 12 on tumor induction by 3-methylcholanthrene. Proc Natl Acad Sci 1996; 93: 11798-801.
22.
Colombo MP, Trinchieri G. Interleukin-12 in anti-tumor immunity and immunotherapy. Cytokine Growth Factor Rev 2002; 13: 155-68.
23.
Eisenring M, vom Berg J, Kristiansen G, et al. IL-12 initiates tumor rejection via lymphoid tissue-inducer cells bearing the natural cytotoxicity receptor NKp46. Nat Immunol 2010; 11: 1030-8.
24.
Langowski JL, Zhang X, Wu L, et al. IL-23 promotes tumour incidence and growth. Nature 2006; 442: 461-5.
25.
Teng MWL, Andrews DM, McLaughlin N, et al. IL-23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasis. Proc Natl Acad Sci 2010; 107: 8328-33.
26.
Schwarz A, Ständer S, Berneburg M, et al. Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair. Nat Cell Biol 2002; 4: 26-31.
27.
Schwarz A, Grabbe S, Aragane Y, et al. Interleukin-12 prevents ultraviolet b-induced local immunosuppression and overcomes UVB-induced tolerance. J Investig Dermatol 1996; 106: 1187-91.
28.
Meeran SM, Mantena SK, Elmets CA, Katiyar SK. (-)-epigallocatechin-3-gallate prevents photocarcinogenesis in mice through interleukin-12-dependent DNA repair. Cancer Res 2006; 66: 5512-20.
29.
Majewski S, Jantschitsch C, Maeda A, et al. IL-23 antagonizes UVR-induced immunosuppression through two mechanisms: reduction of UVR-induced DNA damage and inhibition of UVR-induced regulatory T cells. J Investig Dermatol 2010; 130: 554-62.
30.
Kortylewski M, Xin H, Kujawski M, et al. Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment. Cancer Cell 2009; 15: 114-23.
31.
Nasti TH, Cochran JB, Vachhani RV, et al. IL-23 inhibits melanoma development by augmenting DNA repair and modulating T cell subpopulations. J Immunol 2017; 198: 950-61.
32.
Overwijk WW, de Visser KE, Tirion FH, et al. Immunological and antitumor effects of IL-23 as a cancer vaccine adjuvant. J Immunol 2006; 176: 5213-22.
33.
Fang S, Wang Y, Chun YS, et al. The relationship between blood IL-12p40 level and melanoma progression. Int J Cancer 2015; 136: 1874-80.
34.
Kimball AB, Papp KA, Wasfi Y, et al. Long-term efficacy of ustekinumab in patients with moderate-to-severe psoriasis treated for up to 5 years in the PHOENIX 1 study. J Eur Acad Dermatol Venereol 2013; 27: 1535-45.
35.
Langley RG, Lebwohl M, Krueger GG, et al. Long-term efficacy and safety of ustekinumab, with and without dosing adjustment, in patients with moderate-to-severe psoriasis: results from the PHOENIX 2 study through 5 years of follow-up. Br J Dermatol 2015; 172: 1371-83.
36.
Hu W, Fang L, Ni R, et al. Changing trends in the disease burden of non-melanoma skin cancer globally from 1990 to 2019 and its predicted level in 25 years. BMC Cancer 2022; 22: 836.
37.
Yang K, Oak ASW, Elewski BE. Use of IL-23 inhibitors for the treatment of plaque psoriasis and psoriatic arthritis: a comprehensive review. Am J Clin Dermatol 2021; 22: 173-92.
38.
Blauvelt A, Lebwohl M, Langley RG, et al. Malignancy rates through 5 years of follow-up in patients with moderate-to-severe psoriasis treated with guselkumab: pooled results from the VOYAGE 1 and VOYAGE 2 trials. J Am Acad Dermatol 2023; 89: 274-82.
39.
Thaci D, Piaserico S, Warren RB, et al. Five-year efficacy and safety of tildrakizumab in patients with moderate-to-severe psoriasis who respond at week 28: pooled analyses of two randomized phase III clinical trials (ReSURFACE 1 and ReSURFACE 2)*. Br J Dermatol 2021; 185: 323-34.
40.
Papp KA, Blauvelt A, Puig L, et al. Long-term safety and efficacy of risankizumab for the treatment of moderate-to-severe plaque psoriasis: interim analysis of the LIMMitless Open-Label Extension Trial up to 5 years of follow-up. J Am Acad Dermatol 2023; 89: 1149-58.
41.
Centers for Disease Control and Prevention United States Cancer Statistics: Incidence of Malignant Melanoma of the Skin – United States, 2009-2018. USCS Data Brief, no. 28. Atlanta.
42.
Kridin K, Abdelghaffar M, Mruwat N, et al. Are interleukin 17 and interleukin 23 inhibitors associated with malignancies? Insights from an international population-based study. J Eur Acad Dermatol Venereol 2024; 38: 315-24.
43.
Gaffen SL. Recent advances in the IL-17 cytokine family. Curr Opin Immunol 2011; 23: 613-9.
44.
Brembilla NC, Senra L, Boehncke WH. The IL-17 family of cytokines in psoriasis: IL-17A and beyond. Front Immunol 2018; 9: 1682.
45.
Dong C. Th17 cells in development: an updated view of their molecular identity and genetic programming. Nat Rev Immunol 2008; 8: 337-48.
46.
Amatya N, Garg AV, Gaffen SL. IL-17 signaling: the yin and the yang. Trends Immunol 2017; 38: 310-22.
47.
Awane M, Andres PG, Li DJ, Reinecker HC. NF-Kappa B-inducing kinase is a common mediator of IL-17-, TNF-alpha-, and IL-1 beta-induced chemokine promoter activation in intestinal epithelial cells. J Immunol 1999; 162: 5337-44.
48.
Onishi RM, Gaffen SL. Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease. Immunology 2010; 129: 311-21.
49.
Murugaiyan G, Saha B. Protumor vs antitumor functions of IL-17. J Immunol 2009; 183: 4169-75.
50.
Numasaki M, Watanabe M, Suzuki T, et al. IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis. J Immunol 2005; 175: 6177-89.
51.
Numasaki M. Interleukin-17 promotes angiogenesis and tumor growth. Blood 2003; 101: 2620-7.
52.
Numasaki M, Lotze MT, Sasaki H. Interleukin-17 augments tumor necrosis factor-a-induced elaboration of proangiogenic factors from fibroblasts. Immunol Lett 2004; 93: 39-43.
53.
Honorati MC, Neri S, Cattini L, Facchini A. Interleukin-17, a regulator of angiogenic factor release by synovial fibroblasts. Osteoarthritis Cartilage 2006; 14: 345-52.
54.
De Simone V, Franzè E, Ronchetti G, et al. Th17-type cytokines, IL-6 and TNF-a synergistically activate STAT3 and NF-KB to promote colorectal cancer cell growth. Oncogene 2015; 34: 3493-503.
55.
Jain P, Javdan M, Feger FK, et al. Th17 and non-Th17 interleukin-17-expressing cells in chronic lymphocytic leukemia: delineation, distribution, and clinical relevance. Haematologica 2012; 97: 599-607.
56.
Lu L, Pan K, Zheng HX, et al. IL-17A promotes immune cell recruitment in human esophageal cancers and the infiltrating dendritic cells represent a positive prognostic marker for patient survival. J Immunother 2013; 36: 451-8.
57.
Tong Z, Yang XO, Yan H, et al. A protective role by interleukin-17F in colon tumorigenesis. PLoS One 2012; 7: e34959.
58.
Martin-Orozco N, Muranski P, Chung Y, et al. T helper 17 cells promote cytotoxic t cell activation in tumor immunity. Immunity 2009; 31: 787-98.
59.
Muranski P, Boni A, Antony PA, et al. Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood 2008; 112: 362-73.
60.
Rodriguez C, Araujo Furlan CL, Tosello Boari J, et al. Interleukin-17 signaling influences CD8+ T cell immunity and tumor progression according to the IL-17 receptor subunit expression pattern in cancer cells. Oncoimmunology 2023; 12: 2261326.
61.
Nuñez S, Saez JJ, Fernandez D, et al. T helper type 17 cells contribute to anti-tumour immunity and promote the recruitment of T helper type 1 cells to the tumour. Immunology 2013; 139: 61-71.
62.
Chen YS, Huang TH, Liu CL, et al. Locally targeting the IL-17/IL-17RA axis reduced tumor growth in a murine B16F10 melanoma model. Hum Gene Ther 2019; 30: 273-85.
63.
Wang L, Yi T, Kortylewski M, et al. IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway. J Exp Med 2009; 206: 1457-64.
64.
Tang Q, Li J, Zhu H, et al. Hmgb1-IL-23-IL-17-IL-6-Stat3 axis promotes tumor growth in murine models of melanoma. Mediators Inflamm 2013; 2013: 713859.
65.
Tosi A, Nardinocchi L, Carbone ML, et al. Reduced interleukin-17-expressing cells in cutaneous melanoma. Biomedicines 2021; 9: 1930.
66.
Yan BY, Garcet S, Gulati N, et al. Novel immune signatures associated with dysplastic naevi and primary cutaneous melanoma in human skin. Exp Dermatol 2019; 28: 35-44.
67.
Nardinocchi L, Sonego G, Passarelli F, et al. Interleukin-17 and interleukin-22 promote tumor progression in human nonmelanoma skin cancer. Eur J Immunol 2015; 45: 922-31.
68.
Wu L, Chen X, Zhao J, et al. A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4-ERK5 axis. J Exp Med 2015; 212: 1571-87.
69.
Tuong ZK, Lewandowski A, Bridge JA, et al. Cytokine/chemokine profiles in squamous cell carcinoma correlate with precancerous and cancerous disease stage. Sci Rep 2019; 9: 17754.
70.
Gasparoto TH, de Oliveira CE, de Freitas LT, et al. Inflammatory events during murine squamous cell carcinoma development. J Inflamm 2012; 9: 46.
71.
Pellegrini C, Orlandi A, Costanza G, et al. Expression of IL-23/Th17-related cytokines in basal cell carcinoma and in the response to medical treatments. PLoS One 2017; 12: e0183415.
72.
Hawkes JE, Yan BY, Chan TC, Krueger JG. Discovery of the IL-23/IL-17 signaling pathway and the treatment of psoriasis. J Immunol 2018; 201: 1605-13.
73.
McInnes IB, Mease PJ, Ritchlin CT, et al. Secukinumab sustains improvement in signs and symptoms of psoriatic arthritis: 2 year results from the phase 3 FUTURE 2 study. Rheumatology 2017; 56: 1993-2003.
74.
Smith SD, Stratigos A, Augustin M, et al. Integrated safety analysis on skin cancers among patients with psoriasis receiving ixekizumab in clinical trials. Dermatol Ther (Heidelb) 2023; 13: 1773-87.
75.
Gottlieb A, Lebwohl M, Liu C, et al. Malignancy rates in brodalumab clinical studies for psoriasis. Am J Clin Dermatol 2020; 21: 421-30.
76.
Ritchlin CT, Coates LC, McInnes IB, et al. Bimekizumab treatment in biologic DMARD-naïve patients with active psoriatic arthritis: 52-week efficacy and safety results from the phase III, randomised, placebo-controlled, active reference BE OPTIMAL study. Ann Rheum Dis 2023; 82: 1404-14.