The MCT1 gene Glu490Asp polymorphism (rs1049434)
is associated with endurance athlete status, lower blood lactate
accumulation and higher maximum oxygen uptake

João Paulo Guilherme; Edit Bosnyák; Ekaterina Semenova; Márta Szmodis; Annamária Griff; Ákos Móra; Gábor Almási; Emese Trájer; Anna Udvardy; Elena Kostryukova; Oleg Borisov; Andrey Larin; Liliya Andryushchenko; Egor Akimov; Edward Generozov; Ildus Ahmetov; Miklós Tóth; Antonio Lancha Junior

doi:10.5114/biolsport.2021.101638

eISSN: 2083-1862
ISSN: 0860-021X

Biology of Sport

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3/2021
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abstract:

Original paper

The MCT1 gene Glu490Asp polymorphism (rs1049434) is associated with endurance athlete status, lower blood lactate accumulation and higher maximum oxygen uptake

João Paulo L. F. Guilherme

¹

,

Edit Bosnyák

²

,

Ekaterina A. Semenova

³

,

Márta Szmodis

²

,

Annamária Griff

²

,

Ákos Móra

⁴

,

Gábor Almási

²

,

Emese Trájer

²

,

Anna Udvardy

²

,

Elena S. Kostryukova

³

,

Oleg V. Borisov

^{3, 5}

,

Andrey K. Larin

³

,

Liliya B. Andryushchenko

⁶

,

Egor B. Akimov

⁷

,

Edward V. Generozov

³

,

Ildus I. Ahmetov

^{6, 8, 9, 10}

,

Miklós Tóth

^{2, 4}

,

Antonio H. Lancha Junior

¹

Laboratory of Applied Nutrition and Metabolism, School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil
Department of Health Sciences and Sport Medicine, University of Physical Education, Budapest, Hungary
Department of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia
Faculty of Health Sciences, University of Pécs, Pécs, Hungary
Institute for Genomic Statistics and Bioinformatics, University Hospital Bonn, Bonn, Germany
Department of Physical Education, Plekhanov Russian University of Economics, Moscow, Russia
Central Cross Country Ski Association, Madison, WI, United States of America
Sports Genetics Laboratory, St Petersburg Research Institute of Physical Culture, St Petersburg, Russia
Laboratory of Molecular Genetics, Kazan State Medical University, Kazan, Russia
Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom

Biol Sport. 2021;38(3):465–474

DOI: https://doi.org/10.5114/biolsport.2021.101638

Online publish date: 2020/12/31

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AMA

Guilherme JL, Bosnyák E, Semenova EA, et al. The MCT1 gene Glu490Asp polymorphism (rs1049434)
is associated with endurance athlete status, lower blood lactate
accumulation and higher maximum oxygen uptake. Biology of Sport. 2021;38(3):465-474. doi:10.5114/biolsport.2021.101638.

APA

Guilherme, J. L., Bosnyák, E., Semenova, E. A., Szmodis, M., Griff, A.,  & Móra, Á. et al. (2021). The MCT1 gene Glu490Asp polymorphism (rs1049434)
is associated with endurance athlete status, lower blood lactate
accumulation and higher maximum oxygen uptake. Biology of Sport, 38(3), 465-474. https://doi.org/10.5114/biolsport.2021.101638

Chicago

Guilherme, João Paulo L, Edit Bosnyák, Ekaterina A Semenova, Márta Szmodis, Annamária Griff, Ákos Móra,  and Gábor Almási et al. 2021. "The MCT1 gene Glu490Asp polymorphism (rs1049434)
is associated with endurance athlete status, lower blood lactate
accumulation and higher maximum oxygen uptake". Biology of Sport 38 (3): 465-474. doi:10.5114/biolsport.2021.101638.

Harvard

Guilherme, J., Bosnyák, E., Semenova, E., Szmodis, M., Griff, A., Móra, Á., Almási, G., Trájer, E., Udvardy, A., Kostryukova, E., Borisov, O., Larin, A., Andryushchenko, L., Akimov, E., Generozov, E., Ahmetov, I., Tóth, M.,  and Lancha Junior, A. (2021). The MCT1 gene Glu490Asp polymorphism (rs1049434)
is associated with endurance athlete status, lower blood lactate
accumulation and higher maximum oxygen uptake. Biology of Sport, 38(3), pp.465-474. https://doi.org/10.5114/biolsport.2021.101638

MLA

Guilherme, João Paulo et al. "The MCT1 gene Glu490Asp polymorphism (rs1049434)
is associated with endurance athlete status, lower blood lactate
accumulation and higher maximum oxygen uptake." Biology of Sport, vol. 38, no. 3, 2021, pp. 465-474. doi:10.5114/biolsport.2021.101638.

Vancouver

Guilherme J, Bosnyák E, Semenova E, Szmodis M, Griff A, Móra Á et al. The MCT1 gene Glu490Asp polymorphism (rs1049434)
is associated with endurance athlete status, lower blood lactate
accumulation and higher maximum oxygen uptake. Biology of Sport. 2021;38(3):465-474. doi:10.5114/biolsport.2021.101638.

PlumX metrics:

The purpose of this study was to explore the association of the MCT1 gene Glu490Asp polymorphism (rs1049434) with athletic status and performance of endurance athletes. A total of 1,208 Brazilians (318 endurance athletes and 890 non-athletes) and 867 Europeans (315 endurance athletes and 552 non-athletes) were evaluated in a case–control approach. Brazilian participants were classified based on self-declared ethnicity to test whether the polymorphism was different between Caucasians and Afro-descendants. Moreover, 66 Hungarian athletes underwent an incremental test until exhaustion to assess blood lactate levels, while 46 Russian athletes had their maximum oxygen uptake (O2max) compared between genotypes. In the Brazilian cohort, the major T-allele was more frequent in Caucasian top-level competitors compared to their counterparts of lower competitive level (P = 0.039), and in Afro-descendant athletes compared to non-athletes (P = 0.015). Similarly, the T-allele was more frequent in European athletes (P = 0.029). Meta-analysis of the Brazilian and European cohorts confirmed that the T-allele is over-represented in endurance athletes (OR: 1.48, P = 0.03), especially when Afro-descendant athletes were included in the meta-analysis (OR: 1.58, P = 0.005). Furthermore, carriers of the T/T genotype accumulated less blood lactate in response to intense effort (P<0.01) and exhibited higher O2max (P = 0.04). In conclusion, the Glu490Asp polymorphism was associated with endurance athletic status and performance. Our findings suggest that, although ethnic differences may exist, the presence of the major T-allele (i.e., the Glu-490 allele) favours endurance performance more than the mutant A-allele (i.e., the 490-Asp allele).

keywords:

The MCT1 gene Glu490Asp polymorphism (rs1049434) is associated with endurance athlete status, lower blood lactate accumulation and higher maximum oxygen uptake

Aerobic Performance, Aerobic Power, Athletes, Erythrocytes, Genetics Monocarboxylate Transporter