The antibodies to beta-2-glycoprotein-I in blood serum and aqueous humor in patients with glaucoma

The recent studies tend to consider glaucoma, a leading cause of worldwide blindness, for autoimmunological disorder. The aim of the study was to evaluate frequency of β2-glycoprotein-I antibodies incidence in aqueous humor and serum of glaucoma patients and to estimate the relationship between serum and anterior chamber fluid antibodies in these patients. Samples of blood and anterior chamber fluid were obtained from 21 glaucoma and 27 non glaucoma patients. Incidence of β2-glycoprotein-I antibodies classes IgA and IgG was tested using ELISA method. In the group of glaucoma patients positive ratios were obtained in 8 cases (38%), most frequently in IgA class in aqueous humor (4 cases). The incidence of examined antibodies in anterior chamber fluid was observed in 6 persons (28,5%). In control group positive ratios were observed in 4 cases (15%), most frequently in IgA class in aqueous humor (2 cases). When the ratios were compared between glaucoma and cataract patients, statistically significant differences between β2-glycoprotein-I antibodies class IgA in aqueous humor (p=0.0031) and in serum (p= 0.0005) were observed. The data indicate possible participation of β2-glycoprotein-I antibodies in pathogenesis of glaucoma, yet to determine their pathological and clinical significance further studies are necessary.