| Current supplement Archive Acta Ophthalmologica Polonica |
3/2004
vol. 106 abstract:
Experimental research
The apolipoprotein E polymorphism in age related macular degeneration
Mariusz Nowak
1
,
Elżbieta Świętochowska
2
,
Bożena Szapska
2
,
Bogdan Marek
1
,
Tomasz Wielkoszyński
3
,
Henryk Kozioł
2
,
Joanna Klimek
2
,
Dariusz Kajdaniuk
1
,
Beata Kos-Kudła
4
,
Zofia Ostrowska
2
,
Jacek Karpe
5
,
Joanna Głogowska-Szeląg
1
,
Lucyna Siemińska
1
KLINIKA OCZNA 2004, Supl. 3: S427–S428
Online publish date: 2022/12/29
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Purpose
The aim of the study was to evaluate association of apo E polymorphism with AMD. Material and methods The included participants of this study were: 45 patients aged 60 to 71 (mean age 66,2±3,6), treated because of AMD. Genomic DNA was extracted from peripheral blood leukocytes, and the subsequent analysis of apo E genotypes was performed by polymerase chain reaction (PCR). Results In our study the allele frequencies in control group of patients were similar to the apo E allele distribution presented by other authors in Caucasian populations. We have not found significant differences between AMD and control group patients for apo (E) genotype or allele frequency. Compared with control group (ε4 -13,6%, ε2 -2,27%), the frequency of ε4 allele was not significantly decreased (11,11%) and ε2 allele frequency (7,77%) increased in AMD patients. Conclusions The results of our present study have not indicate a significant association between AMD development and apo E allele frequency, in our studied population of AMD patients. keywords:
AMD, apolipoprotein E, polymorphism |
