The association of oxidative stress of neonatal
hyperbilirubinemia and vitamin E supplementation

Mohamed Zaeim Hafez Ahmed; Reham Helmy Amin Helmy Saad; Ahmad Gadalla; Ramadan Hassan Ibrahim Thabet; Ahmed Abdrabo Elshenawy Elsisi; Ahmed Abdel Nasser Ahmed Mohamed; Mohamed Gaber Abdallah; Tarek Shikhon; Hussien Eleimy Hussien Mohmmed Maged; Muhammad Abdelbaeth Hassan Elfiky; Marwa Fekry Hassan; Fatma Mahmoud Abdelraheem; Ghada Adel Hegazy

doi:10.5114/ceh.2024.136230

eISSN: 2449-8238
ISSN: 2392-1099

Clinical and Experimental Hepatology

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abstract:

Original paper

The association of oxidative stress of neonatal hyperbilirubinemia and vitamin E supplementation

Mohamed Zaeim Hafez Ahmed

¹

,

Reham Helmy Amin Helmy Saad

²

,

Ahmad Gadalla

¹

,

Ramadan Hassan Ibrahim Thabet

³

,

Ahmed Abdrabo Elshenawy Elsisi

³

,

Ahmed Abdel Nasser Ahmed Mohamed

³

,

Mohamed Gaber Abdallah

⁴

,

Tarek Shikhon

⁴

,

Hussien Eleimy Hussien Mohmmed Maged

⁵

,

Muhammad Abdelbaeth Hassan Elfiky

¹

,

Marwa Fekry Hassan

⁶

,

Fatma Mahmoud Abdelraheem

⁷

,

Ghada Adel Hegazy

⁸

Physiology Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt
Pediatrician specialist registrar, M.Sc., Faculty of Medicine, Ain Shams University, Cairo, Egypt
Pharmacology Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt
Biochemistry Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
Pediatric specialist, Fujariah, Fujariah city, United Arab of Emirates
Community and Public Health Department, National Liver Institute, Menoufia University, Shebin elkom, Menoufia, Egypt
Histology and Cell Biology Department, Fuculty of Medicine, Assiut University, Assiut, Egypt
Clinical Pharmacology Department, Faculty of Medicine, Menoufia University, Shebin elkom, Menoufia, Egypt

Clin Exp HEPATOL 2024; 10, 1: 30–38

DOI: https://doi.org/10.5114/ceh.2024.136230

Online publish date: 2024/03/17

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Aim of the study:
Jaundice in newborns is a sign of skin and sclera pigmentation. Hyperbilirubinemia and these phenomena do, however, have a relationship. According to many clinical studies, elevated blood bilirubin and low vitamin E (VE) levels in newborns are associated. The aim of the study was to investigate the association of oxidative stress of neonatal hyperbilirubinemia in patients who underwent phototherapy with additional vitamin E supplementation (25 mg/kg/day over the course of three days) and patients without additional vitamin E.

Material and methods:
A set of 100 neonatal indirect hyperbilirubinemia patients was enrolled at neonatal intensive care units (NICUs) of the pediatric departments at Al Azhar University Hospitals during the period from February 2021 to October 2022 after obtaining signed written informed consent of all neonates’ parents with an explanation of the aim of study.

Results:
Significant differences were found between the studied groups regarding serum bilirubin on the third day of admission (p = 0.039). Patients who were treated with vitamin E had lower serum bilirubin on the third day of admission (8.25 ±3.41) than the control group (11.66 ±3.22). Also, among the VE group, serum bilirubin was significantly decreased on the third day of admission (8.25 ±3.41) compared to zero days of admission (14.10 ±4.39) (p = 0.041).

Conclusions:
Vitamin E supplementation has an important role in treatment of indirect hyperbilirubinemia in neonates. Early administration of vitamin E in preterm neonates resulted in a significant decrease of serum bilirubin and increased total antioxidant capacity. Vitamin E supplementation in full term decreased the duration of phototherapy.